Cargando…

A Comprehensive, Multi-Scale Dynamical Model of ErbB Receptor Signal Transduction in Human Mammary Epithelial Cells

The non-receptor tyrosine kinase Src and receptor tyrosine kinase epidermal growth factor receptor (EGFR/ErbB1) have been established as collaborators in cellular signaling and their combined dysregulation plays key roles in human cancers, including breast cancer. In part due to the complexity of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Helikar, Tomáš, Kochi, Naomi, Kowal, Bryan, Dimri, Manjari, Naramura, Mayumi, Raja, Srikumar M., Band, Vimla, Band, Hamid, Rogers, Jim A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630219/ https://www.ncbi.nlm.nih.gov/pubmed/23637902 http://dx.doi.org/10.1371/journal.pone.0061757

Ejemplares similares

Mechanisms of Trastuzumab resistance in ErbB2-driven breast cancer and newer opportunities to overcome therapy resistance
por: Bailey, Tameka A., et al.
Publicado: (2011)

Continuous requirement of ErbB2 kinase activity for loss of cell polarity and lumen formation in a novel ErbB2/Neu-driven murine cell line model of metastatic breast cancer
por: Ortega-Cava, Cesar F., et al.
Publicado: (2011)

Mammary epithelial cell transformation: insights from cell culture and mouse models
por: Dimri, Goberdhan, et al.
Publicado: (2005)

The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells
por: Malhotra, Gautam K, et al.
Publicado: (2014)

Distinct Effects of EGFR Ligands on Human Mammary Epithelial Cell Differentiation
por: Mukhopadhyay, Chandrani, et al.
Publicado: (2013)

Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibition
por: Raja, Srikumar M., et al.
Publicado: (2016)

Negative Regulation of EGFR-Vav2 Signaling Axis by Cbl Ubiquitin Ligase Controls EGF Receptor-mediated Epithelial Cell Adherens Junction Dynamics and Cell Migration
por: Duan, Lei, et al.
Publicado: (2011)

CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation
por: Luan, Haitao, et al.
Publicado: (2021)

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders
por: Naramura, Mayumi, et al.
Publicado: (2011)

The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants
por: Chung, Byung Min, et al.
Publicado: (2009)

Proliferation of Colorectal Cancer Is Promoted by Two Signaling Transduction Expression Patterns: ErbB2/ErbB3/AKT and MET/ErbB3/MAPK
por: Yao, Yong-Liang, et al.
Publicado: (2013)

Pathway pathology: the wnt and erbB mammary tumors
por: Rosner, A, et al.
Publicado: (2001)

Derivation of Myoepithelial Progenitor Cells from Bipotent Mammary Stem/Progenitor Cells
por: Zhao, Xiangshan, et al.
Publicado: (2012)

Effects of ErbB2 Overexpression on the Proteome and ErbB Ligand-specific Phosphosignaling in Mammary Luminal Epithelial Cells
por: Worthington, Jenny, et al.
Publicado: (2017)

A block in lineage differentiation of immortal human mammary stem / progenitor cells by ectopically-expressed oncogenes
por: Zhao, Xiangshan, et al.
Publicado: (2011)

Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo
por: Lahlou, Hicham, et al.
Publicado: (2012)

Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3
por: Young, Christian D, et al.
Publicado: (2008)

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src(@)
por: Chung, Byung Min, et al.
Publicado: (2009)

ErbB3 is required for ductal morphogenesis in the mouse mammary gland
por: Jackson-Fisher, Amy J, et al.
Publicado: (2008)

Transcriptional profiling of ErbB signalling in mammary luminal epithelial cells - interplay of ErbB and IGF1 signalling through IGFBP3 regulation
por: Worthington, Jenny, et al.
Publicado: (2010)

Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice
por: Parris, Amanda B., et al.
Publicado: (2017)

c-erbB-3: a nuclear protein in mammary epithelial cells
por: Offterdinger, Martin, et al.
Publicado: (2002)

The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells
por: Muraoka-Cook, RS, et al.
Publicado: (2005)

Pparγ1 Facilitates ErbB2-Mammary Adenocarcinoma in Mice
por: Jiao, Xuanmao, et al.
Publicado: (2021)

Modulation of ErbB2 Blockade in ErbB2-Positive Cancers: The Role of ErbB2 Mutations and PHLDA1
por: Li, Guangyuan, et al.
Publicado: (2014)

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells
por: Zhang, Yi, et al.
Publicado: (2009)

Mammary Cells with Active Wnt Signaling Resist ErbB2-Induced Tumorigenesis
por: Bu, Wen, et al.
Publicado: (2013)

The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis
por: Wellberg, Elizabeth A., et al.
Publicado: (2016)

ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation
por: Williams, Michelle M., et al.
Publicado: (2017)

Endocrine resistance in breast cancer: new roles for ErbB3 and ErbB4
por: Sutherland, Robert L
Publicado: (2011)

Mutational Screening in Tyrosine-Kinase Domain of erbB1 And erbB2 Genes
por: ALONSO, Juan Manuel Fernández
Publicado: (2005)

ErbB activation signatures as potential biomarkers for anti-ErbB3 treatment in HNSCC
por: Alvarado, Diego, et al.
Publicado: (2017)

Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice
por: Calogero, Raffaele Adolfo, et al.
Publicado: (2007)

Selective Roles of E2Fs for ErbB2- and Myc-mediated Mammary Tumorigenesis
por: Wu, Lizhao, et al.
Publicado: (2013)

ErbB2 copy number gain is associated with adverse outcome in canine mammary carcinoma
por: SAKAI, Kosei, et al.
Publicado: (2021)

Expression of oncogenes in thyroid tumours: coexpression of c-erbB2/neu and c-erbB.
por: Aasland, R., et al.
Publicado: (1988)

Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer
por: Wolfson, Eya, et al.
Publicado: (2018)

Nucleolin-binding by ErbB2 enhances tumorigenicity of ErbB2-positive breast cancer
por: Wolfson, Eya, et al.
Publicado: (2016)

Sensitivity analysis of biological Boolean networks using information fusion based on nonadditive set functions
por: Kochi, Naomi, et al.
Publicado: (2014)

Bio-Logic Builder: A Non-Technical Tool for Building Dynamical, Qualitative Models
por: Helikar, Tomáš, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_f4r4p7q4vmqprnug45v62v4rkj