Cargando…

Comparative Studies on the Dissolution Profiles of Oral Ibuprofen Suspension and Commercial Tablets using Biopharmaceutical Classification System Criteria

In vitro dissolution studies for solid oral dosage forms have recently widened the scope to a variety of special dosage forms such as suspensions. For class II drugs, like Ibuprofen, it is very important to have discriminative methods for different formulations in physiological conditions of the gas...

Descripción completa

Detalles Bibliográficos
Autores principales: Rivera-Leyva, J. C., García-Flores, M., Valladares-Méndez, A., Orozco-Castellanos, L. M., Martínez-Alfaro, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630726/
https://www.ncbi.nlm.nih.gov/pubmed/23626386
http://dx.doi.org/10.4103/0250-474X.107062
_version_ 1782266719360778240
author Rivera-Leyva, J. C.
García-Flores, M.
Valladares-Méndez, A.
Orozco-Castellanos, L. M.
Martínez-Alfaro, M.
author_facet Rivera-Leyva, J. C.
García-Flores, M.
Valladares-Méndez, A.
Orozco-Castellanos, L. M.
Martínez-Alfaro, M.
author_sort Rivera-Leyva, J. C.
collection PubMed
description In vitro dissolution studies for solid oral dosage forms have recently widened the scope to a variety of special dosage forms such as suspensions. For class II drugs, like Ibuprofen, it is very important to have discriminative methods for different formulations in physiological conditions of the gastrointestinal tract, which will identify different problems that compromise the drug bioavailability. In the present work, two agitation speeds have been performed in order to study ibuprofen suspension dissolution. The suspensions have been characterised relatively to particle size, density and solubility. The dissolution study was conducted using the following media: buffer pH 7.2, pH 6.8, 4.5 and 0.1 M HCl. For quantitative analysis, the UV/Vis spectrophotometry was used because this methodology had been adequately validated. The results show that 50 rpm was the adequate condition to discriminate the dissolution profile. The suspension kinetic release was found to be dependent on pH and was different compared to tablet release profile at the same experimental conditions. The ibuprofen release at pH 1.0 was the slowest.
format Online
Article
Text
id pubmed-3630726
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-36307262013-04-26 Comparative Studies on the Dissolution Profiles of Oral Ibuprofen Suspension and Commercial Tablets using Biopharmaceutical Classification System Criteria Rivera-Leyva, J. C. García-Flores, M. Valladares-Méndez, A. Orozco-Castellanos, L. M. Martínez-Alfaro, M. Indian J Pharm Sci Research Paper In vitro dissolution studies for solid oral dosage forms have recently widened the scope to a variety of special dosage forms such as suspensions. For class II drugs, like Ibuprofen, it is very important to have discriminative methods for different formulations in physiological conditions of the gastrointestinal tract, which will identify different problems that compromise the drug bioavailability. In the present work, two agitation speeds have been performed in order to study ibuprofen suspension dissolution. The suspensions have been characterised relatively to particle size, density and solubility. The dissolution study was conducted using the following media: buffer pH 7.2, pH 6.8, 4.5 and 0.1 M HCl. For quantitative analysis, the UV/Vis spectrophotometry was used because this methodology had been adequately validated. The results show that 50 rpm was the adequate condition to discriminate the dissolution profile. The suspension kinetic release was found to be dependent on pH and was different compared to tablet release profile at the same experimental conditions. The ibuprofen release at pH 1.0 was the slowest. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3630726/ /pubmed/23626386 http://dx.doi.org/10.4103/0250-474X.107062 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Rivera-Leyva, J. C.
García-Flores, M.
Valladares-Méndez, A.
Orozco-Castellanos, L. M.
Martínez-Alfaro, M.
Comparative Studies on the Dissolution Profiles of Oral Ibuprofen Suspension and Commercial Tablets using Biopharmaceutical Classification System Criteria
title Comparative Studies on the Dissolution Profiles of Oral Ibuprofen Suspension and Commercial Tablets using Biopharmaceutical Classification System Criteria
title_full Comparative Studies on the Dissolution Profiles of Oral Ibuprofen Suspension and Commercial Tablets using Biopharmaceutical Classification System Criteria
title_fullStr Comparative Studies on the Dissolution Profiles of Oral Ibuprofen Suspension and Commercial Tablets using Biopharmaceutical Classification System Criteria
title_full_unstemmed Comparative Studies on the Dissolution Profiles of Oral Ibuprofen Suspension and Commercial Tablets using Biopharmaceutical Classification System Criteria
title_short Comparative Studies on the Dissolution Profiles of Oral Ibuprofen Suspension and Commercial Tablets using Biopharmaceutical Classification System Criteria
title_sort comparative studies on the dissolution profiles of oral ibuprofen suspension and commercial tablets using biopharmaceutical classification system criteria
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630726/
https://www.ncbi.nlm.nih.gov/pubmed/23626386
http://dx.doi.org/10.4103/0250-474X.107062
work_keys_str_mv AT riveraleyvajc comparativestudiesonthedissolutionprofilesoforalibuprofensuspensionandcommercialtabletsusingbiopharmaceuticalclassificationsystemcriteria
AT garciafloresm comparativestudiesonthedissolutionprofilesoforalibuprofensuspensionandcommercialtabletsusingbiopharmaceuticalclassificationsystemcriteria
AT valladaresmendeza comparativestudiesonthedissolutionprofilesoforalibuprofensuspensionandcommercialtabletsusingbiopharmaceuticalclassificationsystemcriteria
AT orozcocastellanoslm comparativestudiesonthedissolutionprofilesoforalibuprofensuspensionandcommercialtabletsusingbiopharmaceuticalclassificationsystemcriteria
AT martinezalfarom comparativestudiesonthedissolutionprofilesoforalibuprofensuspensionandcommercialtabletsusingbiopharmaceuticalclassificationsystemcriteria