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The Study of Anticancer and Antifungal Activities of Pistacia integerrima Extract in vitro
Pistacia integerrima Stew. ex Brand (Anacardiaceae) is an ethanobotanically important plant species traditionally used in the treatment of chronic wounds, jaundice, dysentery, etc. The crude extract from Pistacia integerrima and its fractions were tested for cytotoxic activity against Michigan Cance...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630737/ https://www.ncbi.nlm.nih.gov/pubmed/23626397 http://dx.doi.org/10.4103/0250-474X.107085 |
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author | Bibi, Y. Nisa, S. Zia, M. Waheed, A. Ahmed, S. Chaudhary, M. F. |
author_facet | Bibi, Y. Nisa, S. Zia, M. Waheed, A. Ahmed, S. Chaudhary, M. F. |
author_sort | Bibi, Y. |
collection | PubMed |
description | Pistacia integerrima Stew. ex Brand (Anacardiaceae) is an ethanobotanically important plant species traditionally used in the treatment of chronic wounds, jaundice, dysentery, etc. The crude extract from Pistacia integerrima and its fractions were tested for cytotoxic activity against Michigan Cancer Foundation-7 human breast cancer cell line. We have also investigated that crude stem extract of this plant also exhibits the antitumour as well as antifungal potential activities. Moreover, we have also studied that the crude extract inhibited Michigan Cancer Foundation-7 cell viability in a dose-dependent manner; the poor toxicity (1.6%) at 10 μg/ml to moderate toxicity (55.4%) at 100 μg/ml. The IC(50) values calculated were 90.9 μg/ml. The ethyl acetate and chloroform fractions at a concentration of 200 μg/ml showed ~100 and 97.4% inhibition against Michigan Cancer Foundation-7 cell line, respectively. The crude methanol extract also showed good antitumour (IC(50) 125 ppm) activity, but weak antifungal activity. These findings reveal that the ethyl acetate and chloroform fractions of Pistacia integerrima are potent cytotoxic fractions, and could be an alternate candidate for the development of novel biologically active compounds. |
format | Online Article Text |
id | pubmed-3630737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36307372013-04-26 The Study of Anticancer and Antifungal Activities of Pistacia integerrima Extract in vitro Bibi, Y. Nisa, S. Zia, M. Waheed, A. Ahmed, S. Chaudhary, M. F. Indian J Pharm Sci Short Communication Pistacia integerrima Stew. ex Brand (Anacardiaceae) is an ethanobotanically important plant species traditionally used in the treatment of chronic wounds, jaundice, dysentery, etc. The crude extract from Pistacia integerrima and its fractions were tested for cytotoxic activity against Michigan Cancer Foundation-7 human breast cancer cell line. We have also investigated that crude stem extract of this plant also exhibits the antitumour as well as antifungal potential activities. Moreover, we have also studied that the crude extract inhibited Michigan Cancer Foundation-7 cell viability in a dose-dependent manner; the poor toxicity (1.6%) at 10 μg/ml to moderate toxicity (55.4%) at 100 μg/ml. The IC(50) values calculated were 90.9 μg/ml. The ethyl acetate and chloroform fractions at a concentration of 200 μg/ml showed ~100 and 97.4% inhibition against Michigan Cancer Foundation-7 cell line, respectively. The crude methanol extract also showed good antitumour (IC(50) 125 ppm) activity, but weak antifungal activity. These findings reveal that the ethyl acetate and chloroform fractions of Pistacia integerrima are potent cytotoxic fractions, and could be an alternate candidate for the development of novel biologically active compounds. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3630737/ /pubmed/23626397 http://dx.doi.org/10.4103/0250-474X.107085 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Bibi, Y. Nisa, S. Zia, M. Waheed, A. Ahmed, S. Chaudhary, M. F. The Study of Anticancer and Antifungal Activities of Pistacia integerrima Extract in vitro |
title | The Study of Anticancer and Antifungal Activities of Pistacia integerrima Extract in vitro |
title_full | The Study of Anticancer and Antifungal Activities of Pistacia integerrima Extract in vitro |
title_fullStr | The Study of Anticancer and Antifungal Activities of Pistacia integerrima Extract in vitro |
title_full_unstemmed | The Study of Anticancer and Antifungal Activities of Pistacia integerrima Extract in vitro |
title_short | The Study of Anticancer and Antifungal Activities of Pistacia integerrima Extract in vitro |
title_sort | study of anticancer and antifungal activities of pistacia integerrima extract in vitro |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630737/ https://www.ncbi.nlm.nih.gov/pubmed/23626397 http://dx.doi.org/10.4103/0250-474X.107085 |
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