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Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing
Little is known about the processes that enable influenza A viruses to jump into new host species. Here we show that the non-structural protein1 nucleotide substitution, A374G, encoding the D125G(GAT→GGT) mutation, which evolved during the adaptation of a human virus within a mouse host, activates a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630925/ https://www.ncbi.nlm.nih.gov/pubmed/26038410 http://dx.doi.org/10.1038/emi.2012.38 |