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T-cell responses in hepatitis B and C virus infection: similarities and differences

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are global health problems affecting 600 million people worldwide. Indeed, HBV and HCV are hepatotropic viruses that can cause acute and chronic liver disease progressing to liver cirrhosis and even hepatocellular carcinoma. Furth...

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Autores principales: Schmidt, Julia, Blum, Hubert E, Thimme, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630955/
https://www.ncbi.nlm.nih.gov/pubmed/26038456
http://dx.doi.org/10.1038/emi.2013.14
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author Schmidt, Julia
Blum, Hubert E
Thimme, Robert
author_facet Schmidt, Julia
Blum, Hubert E
Thimme, Robert
author_sort Schmidt, Julia
collection PubMed
description Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are global health problems affecting 600 million people worldwide. Indeed, HBV and HCV are hepatotropic viruses that can cause acute and chronic liver disease progressing to liver cirrhosis and even hepatocellular carcinoma. Furthermore, co-infections of HBV and HCV with HIV are emerging worldwide. These co-infections are even more likely to develop persistent infection and are difficult to treat. There is growing evidence that virus-specific CD4(+) and CD8(+) T-cell responses play a central role in the outcome and pathogenesis of HBV and HCV infection. While virus-specific T-cell responses are able to successfully clear the virus in a subpopulation of patients, failure of these T-cell responses is associated with the development of viral persistence. In this review article, we will discuss similarities and differences in HBV- and HCV-specific T-cell responses that are central in determining viral clearance, persistence and liver disease.
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spelling pubmed-36309552013-05-13 T-cell responses in hepatitis B and C virus infection: similarities and differences Schmidt, Julia Blum, Hubert E Thimme, Robert Emerg Microbes Infect Review Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are global health problems affecting 600 million people worldwide. Indeed, HBV and HCV are hepatotropic viruses that can cause acute and chronic liver disease progressing to liver cirrhosis and even hepatocellular carcinoma. Furthermore, co-infections of HBV and HCV with HIV are emerging worldwide. These co-infections are even more likely to develop persistent infection and are difficult to treat. There is growing evidence that virus-specific CD4(+) and CD8(+) T-cell responses play a central role in the outcome and pathogenesis of HBV and HCV infection. While virus-specific T-cell responses are able to successfully clear the virus in a subpopulation of patients, failure of these T-cell responses is associated with the development of viral persistence. In this review article, we will discuss similarities and differences in HBV- and HCV-specific T-cell responses that are central in determining viral clearance, persistence and liver disease. Nature Publishing Group 2013-03 2013-03-27 /pmc/articles/PMC3630955/ /pubmed/26038456 http://dx.doi.org/10.1038/emi.2013.14 Text en Copyright © 2013 Shanghai Shangyixun Cultural Communication Co., Ltd http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Schmidt, Julia
Blum, Hubert E
Thimme, Robert
T-cell responses in hepatitis B and C virus infection: similarities and differences
title T-cell responses in hepatitis B and C virus infection: similarities and differences
title_full T-cell responses in hepatitis B and C virus infection: similarities and differences
title_fullStr T-cell responses in hepatitis B and C virus infection: similarities and differences
title_full_unstemmed T-cell responses in hepatitis B and C virus infection: similarities and differences
title_short T-cell responses in hepatitis B and C virus infection: similarities and differences
title_sort t-cell responses in hepatitis b and c virus infection: similarities and differences
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630955/
https://www.ncbi.nlm.nih.gov/pubmed/26038456
http://dx.doi.org/10.1038/emi.2013.14
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