Cargando…

Sorafenib Inhibits Lymphoma Xenografts by Targeting MAPK/ERK and AKT Pathways in Tumor and Vascular Cells

The anti-lymphoma activity and mechanism(s) of action of the multikinase inhibitor sorafenib were investigated using a panel of lymphoma cell lines, including SU-DHL-4V, Granta-519, HD-MyZ, and KMS-11 cell lines. In vitro, sorafenib significantly decreased cell proliferation and phosphorylation leve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carlo-Stella, Carmelo, Locatelli, Silvia L., Giacomini, Arianna, Cleris, Loredana, Saba, Elena, Righi, Marco, Guidetti, Anna, Gianni, Alessandro M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631141/ https://www.ncbi.nlm.nih.gov/pubmed/23620775 http://dx.doi.org/10.1371/journal.pone.0061603

Ejemplares similares

D Quantification of Tumor Vasculature in Lymphoma Xenografts in NOD/SCID Mice Allows to Detect Differences among Vascular-Targeted Therapies
por: Righi, Marco, et al.
Publicado: (2013)

Correction: D Quantification of Tumor Vasculature in Lymphoma Xenografts in NOD/SCID Mice Allows to Detect Differences among Vascular-Targeted Therapies
por: Righi, Marco, et al.
Publicado: (2013)

Vascular amounts and dispersion of caliber-classified vessels as key parameters to quantitate 3D micro-angioarchitectures in multiple myeloma experimental tumors
por: Righi, Marco, et al.
Publicado: (2018)

The Detection and Morphological Analysis of Circulating Tumor and Host Cells in Breast Cancer Xenograft Models
por: Cleris, Loredana, et al.
Publicado: (2019)

Dual PI3K/ERK inhibition induces necroptotic cell death of Hodgkin Lymphoma cells through IER3 downregulation
por: Locatelli, Silvia Laura, et al.
Publicado: (2016)

Sorafenib exerts an anti-keloid activity by antagonizing TGF-β/Smad and MAPK/ERK signaling pathways
por: Wang, Wenbo, et al.
Publicado: (2016)

Metformin Enhances the Anti-Cancer Efficacy of Sorafenib via Suppressing MAPK/ERK/Stat3 Axis in Hepatocellular Carcinoma
por: Siddharth, Sumit, et al.
Publicado: (2022)

MAPK-ERK Pathway
por: Park, Jong-In
Publicado: (2023)

Hesperetin Inhibits Vascular Formation by Suppressing of the PI3K/AKT, ERK, and p38 MAPK Signaling Pathways
por: Kim, Gi Dae
Publicado: (2014)

Dynamic Modeling and Analysis of the Cross-Talk between Insulin/AKT and MAPK/ERK Signaling Pathways
por: Arkun, Yaman
Publicado: (2016)

Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71
por: Wong, Wen-Rou, et al.
Publicado: (2005)

Effect of sorafenib combined with cytostatic agents on hepatoblastoma cell lines and xenografts
por: Eicher, C, et al.
Publicado: (2013)

pERK/pAkt phenotyping in circulating tumor cells as a biomarker for sorafenib efficacy in patients with advanced hepatocellular carcinoma
por: Li, Jun, et al.
Publicado: (2015)

Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine
por: Musazzi, Laura, et al.
Publicado: (2014)

The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas
por: Du, Juan, et al.
Publicado: (2016)

Effects of evodiamine on PI3K/Akt and MAPK/ERK signaling pathways in pancreatic cancer cells
por: Hong, Zhong, et al.
Publicado: (2020)

Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion
por: Serrano-Oviedo, Leticia, et al.
Publicado: (2018)

ERK/MAPK signalling pathway and tumorigenesis
por: Guo, Yan-Jun, et al.
Publicado: (2020)

Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion
por: Zhou, Jing, et al.
Publicado: (2015)

Cannabidiol‐mediated RISK PI3K/AKT and MAPK/ERK pathways decreasing reperfusion myocardial damage
por: Franco‐Vadillo, Antonio, et al.
Publicado: (2021)

EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in non-small cell lung cancer cells
por: Gao, Lei, et al.
Publicado: (2021)

Quantification of 3D Brain Microangioarchitectures in an Animal Model of Krabbe Disease
por: Righi, Marco, et al.
Publicado: (2019)

Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes
por: Chae, Jae Kyoung, et al.
Publicado: (2017)

Regulation of ERK-MAPK signaling in human epidermis
por: Cursons, Joseph, et al.
Publicado: (2015)

MAPK/ERK Signaling in Regulation of Renal Differentiation
por: Kurtzeborn, Kristen, et al.
Publicado: (2019)

MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma
por: Moon, Hyuk, et al.
Publicado: (2021)

Navigating the ERK1/2 MAPK Cascade
por: Martin-Vega, Ana, et al.
Publicado: (2023)

Surveillance of spontaneous breast cancer metastasis by TRAIL-expressing CD34(+) cells in a xenograft model
por: Rossini, Anna, et al.
Publicado: (2012)

IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways
por: Cai, Wenpeng, et al.
Publicado: (2023)

Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt’s lymphoma cells by inhibiting AKT and ERK
por: Yuan-Ce, Li, et al.
Publicado: (2023)

Phosphorylated ERK is a potential prognostic biomarker for Sorafenib response in hepatocellular carcinoma
por: Liang, Yuelong, et al.
Publicado: (2017)

Antrodia cinnamomea boosts the anti-tumor activity of sorafenib in xenograft models of human hepatocellular carcinoma
por: Wu, Wei-De, et al.
Publicado: (2018)

CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways
por: Yu, Shi-Tong, et al.
Publicado: (2018)

Genistein Protects Genioglossus Myoblast Against Hypoxia-induced Injury through PI3K-Akt and ERK MAPK Pathways
por: Ding, Wanghui, et al.
Publicado: (2017)

EMODIN EFFICACY ON THE AKT, MAPK, ERK AND DNMT EXPRESSION PATTERN DURING DMBA-INDUCED ORAL CARCINOMA IN GOLDEN SYRIAN HAMSTERS
por: Manimaran, Asokan, et al.
Publicado: (2016)

Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma
por: Yu, Xiying, et al.
Publicado: (2020)

PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma
por: Corrales, Eyleen, et al.
Publicado: (2022)

PDE4D targeting enhances anti-tumor effects of sorafenib in clear cell renal cell carcinoma and attenuates MAPK/ERK signaling in a CRAF-dependent manner
por: Cao, Minghua, et al.
Publicado: (2022)

Activation of MAPK ERK in peripheral nerve after injury
por: Agthong, S, et al.
Publicado: (2006)

The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis
por: Kim, Jung-Min, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9jrco6v1puhlbiu8jvjglkned4