Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases

The ability to precisely upregulate genes in inflamed brain holds great therapeutic promise. Here we report a novel class of vectors, genetically modified macrophages that carry reporter and therapeutic genes to neural cells. Systemic administration of macrophages transfected ex vivo with a plasmid...

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Detalles Bibliográficos
Autores principales: Haney, Matthew J., Zhao, Yuling, Harrison, Emily B., Mahajan, Vivek, Ahmed, Shaheen, He, Zhijian, Suresh, Poornima, Hingtgen, Shawn D., Klyachko, Natalia L., Mosley, R. Lee, Gendelman, Howard E., Kabanov, Alexander V., Batrakova, Elena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631190/
https://www.ncbi.nlm.nih.gov/pubmed/23620794
http://dx.doi.org/10.1371/journal.pone.0061852

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