Simultaneous Binding of the Anti-Cancer IgM Monoclonal Antibody PAT-SM6 to Low Density Lipoproteins and GRP78

The tumour-derived monoclonal IgM antibody PAT-SM6 specifically kills malignant cells by an apoptotic mechanism linked to the excessive uptake of plasma lipids. The mechanism is postulated to occur via the multi-point attachment of PAT-SM6 to the unfolded protein response regulator GRP78, located on...

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Detalles Bibliográficos
Autores principales: Rosenes, Zachary, Mok, Yee-Foong, Yang, Shuo, Griffin, Michael D. W., Mulhern, Terrence D., Hatters, Danny M., Hensel, Frank, Howlett, Geoffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631193/
https://www.ncbi.nlm.nih.gov/pubmed/23620733
http://dx.doi.org/10.1371/journal.pone.0061239

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