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The Diminished Expression of Proangiogenic Growth Factors and Their Receptors in Gastric Ulcers of Cirrhotic Patients

OBJECTIVES: The pathogenesis of the higher occurrence of peptic ulcer disease in cirrhotic patients is complex. Platelets can stimulate angiogenesis and promote gastric ulcer healing. We compared the expressions of proangiogenic growth factors and their receptors in the gastric ulcer margin between...

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Autores principales: Luo, Jiing-Chyuan, Peng, Yen-Ling, Hou, Ming-Chih, Huang, Kuang-Wei, Huang, Hui-Chun, Wang, Ying-Wen, Lin, Han-Chieh, Lee, Fa-Yauh, Lu, Ching-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631223/
https://www.ncbi.nlm.nih.gov/pubmed/23620752
http://dx.doi.org/10.1371/journal.pone.0061426
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author Luo, Jiing-Chyuan
Peng, Yen-Ling
Hou, Ming-Chih
Huang, Kuang-Wei
Huang, Hui-Chun
Wang, Ying-Wen
Lin, Han-Chieh
Lee, Fa-Yauh
Lu, Ching-Liang
author_facet Luo, Jiing-Chyuan
Peng, Yen-Ling
Hou, Ming-Chih
Huang, Kuang-Wei
Huang, Hui-Chun
Wang, Ying-Wen
Lin, Han-Chieh
Lee, Fa-Yauh
Lu, Ching-Liang
author_sort Luo, Jiing-Chyuan
collection PubMed
description OBJECTIVES: The pathogenesis of the higher occurrence of peptic ulcer disease in cirrhotic patients is complex. Platelets can stimulate angiogenesis and promote gastric ulcer healing. We compared the expressions of proangiogenic growth factors and their receptors in the gastric ulcer margin between cirrhotic patients with thrombocytopenia and those of non-cirrhotic patients to elucidate possible mechanisms. METHODS: Eligible cirrhotic patients (n = 55) and non-cirrhotic patients (n = 55) who had gastric ulcers were enrolled. Mucosa from the gastric ulcer margin and non-ulcer areas were sampled and the mRNA expressions of the proangiogenic growth factors (vascular endothelial growth factor [VEGF], platelet derived growth factor [PDGF], basic fibroblast growth factor [bFGF]) and their receptors (VEGFR1, VEGFR2, PDGFRA, PDGFRB, FGFR1, FGFR2) were measured and compared. Platelet count and the expressions of these growth factors and their receptors were correlated with each other. RESULTS: The two groups were comparable in terms of gender, ulcer size and infection rate of Helicobacter pylori. However, the cirrhotic group were younger in age, had a lower platelet count than those in the non-cirrhotic group (p<0.05). The cirrhotic patients had diminished mRNA expressions of PDGFB, VEGFR2, FGFR1, and FGFR2 in gastric ulcer margin when compared with those of the non-cirrhotic patients (p<0.05). Diminished expressions of PDGFB and VEGFR2, FGFR1, and FGFR2 were well correlated with the degree of thrombocytopenia in these cirrhotic patients (ρ>0.5, p<0.001). CONCLUSIONS: Our findings implied that diminished activity of proangiogenic factors and their receptors may contribute to the pathogenesis of gastric ulcers in cirrhotic patients.
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spelling pubmed-36312232013-04-25 The Diminished Expression of Proangiogenic Growth Factors and Their Receptors in Gastric Ulcers of Cirrhotic Patients Luo, Jiing-Chyuan Peng, Yen-Ling Hou, Ming-Chih Huang, Kuang-Wei Huang, Hui-Chun Wang, Ying-Wen Lin, Han-Chieh Lee, Fa-Yauh Lu, Ching-Liang PLoS One Research Article OBJECTIVES: The pathogenesis of the higher occurrence of peptic ulcer disease in cirrhotic patients is complex. Platelets can stimulate angiogenesis and promote gastric ulcer healing. We compared the expressions of proangiogenic growth factors and their receptors in the gastric ulcer margin between cirrhotic patients with thrombocytopenia and those of non-cirrhotic patients to elucidate possible mechanisms. METHODS: Eligible cirrhotic patients (n = 55) and non-cirrhotic patients (n = 55) who had gastric ulcers were enrolled. Mucosa from the gastric ulcer margin and non-ulcer areas were sampled and the mRNA expressions of the proangiogenic growth factors (vascular endothelial growth factor [VEGF], platelet derived growth factor [PDGF], basic fibroblast growth factor [bFGF]) and their receptors (VEGFR1, VEGFR2, PDGFRA, PDGFRB, FGFR1, FGFR2) were measured and compared. Platelet count and the expressions of these growth factors and their receptors were correlated with each other. RESULTS: The two groups were comparable in terms of gender, ulcer size and infection rate of Helicobacter pylori. However, the cirrhotic group were younger in age, had a lower platelet count than those in the non-cirrhotic group (p<0.05). The cirrhotic patients had diminished mRNA expressions of PDGFB, VEGFR2, FGFR1, and FGFR2 in gastric ulcer margin when compared with those of the non-cirrhotic patients (p<0.05). Diminished expressions of PDGFB and VEGFR2, FGFR1, and FGFR2 were well correlated with the degree of thrombocytopenia in these cirrhotic patients (ρ>0.5, p<0.001). CONCLUSIONS: Our findings implied that diminished activity of proangiogenic factors and their receptors may contribute to the pathogenesis of gastric ulcers in cirrhotic patients. Public Library of Science 2013-04-19 /pmc/articles/PMC3631223/ /pubmed/23620752 http://dx.doi.org/10.1371/journal.pone.0061426 Text en © 2013 Luo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Luo, Jiing-Chyuan
Peng, Yen-Ling
Hou, Ming-Chih
Huang, Kuang-Wei
Huang, Hui-Chun
Wang, Ying-Wen
Lin, Han-Chieh
Lee, Fa-Yauh
Lu, Ching-Liang
The Diminished Expression of Proangiogenic Growth Factors and Their Receptors in Gastric Ulcers of Cirrhotic Patients
title The Diminished Expression of Proangiogenic Growth Factors and Their Receptors in Gastric Ulcers of Cirrhotic Patients
title_full The Diminished Expression of Proangiogenic Growth Factors and Their Receptors in Gastric Ulcers of Cirrhotic Patients
title_fullStr The Diminished Expression of Proangiogenic Growth Factors and Their Receptors in Gastric Ulcers of Cirrhotic Patients
title_full_unstemmed The Diminished Expression of Proangiogenic Growth Factors and Their Receptors in Gastric Ulcers of Cirrhotic Patients
title_short The Diminished Expression of Proangiogenic Growth Factors and Their Receptors in Gastric Ulcers of Cirrhotic Patients
title_sort diminished expression of proangiogenic growth factors and their receptors in gastric ulcers of cirrhotic patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631223/
https://www.ncbi.nlm.nih.gov/pubmed/23620752
http://dx.doi.org/10.1371/journal.pone.0061426
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