Ligand-binding dynamics rewire cellular signaling via Estrogen Receptor-α

Ligand-binding dynamics control allosteric signaling through the estrogen receptor-α (ERα), but the biological consequences of such dynamic binding orientations are unknown. Here, we compare a set of ER ligands having dynamic binding orientation (dynamic ligands) with a control set of isomers that a...

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Detalles Bibliográficos
Autores principales: Srinivasan, Sathish, Nwachukwu, Jerome C., Parent, Alex A., Cavett, Valerie, Nowak, Jason, Hughes, Travis S., Kojetin, Douglas J., Katzenellenbogen, John A., Nettles, Kendall W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631275/
https://www.ncbi.nlm.nih.gov/pubmed/23524984
http://dx.doi.org/10.1038/nchembio.1214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631275/
https://www.ncbi.nlm.nih.gov/pubmed/23524984
http://dx.doi.org/10.1038/nchembio.1214

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