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Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)–S cell cycle transition in radioresistance of perinecrotic tumor cells

Cancer patients often suffer from local tumor recurrence after radiation therapy. Some intracellular and extracellular factors, such as activity of hypoxia-inducible factor 1 (HIF-1), cell cycle status and oxygen availability, have been suggested to affect DNA damage responses and eventual radioresi...

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Detalles Bibliográficos
Autores principales:	Zhu, Y, Zhao, T, Itasaka, S, Zeng, L, Yeom, C J, Hirota, K, Suzuki, K, Morinibu, A, Shinomiya, K, Ou, G, Yoshimura, M, Hiraoka, M, Harada, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631307/ https://www.ncbi.nlm.nih.gov/pubmed/22710721 http://dx.doi.org/10.1038/onc.2012.223

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