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Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies

OBJECTIVE: To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: A systematic search of the MEDLINE and Embase databases and a hand search of references from original r...

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Autores principales: Song, Yiqing, Wang, Lu, Pittas, Anastassios G., Del Gobbo, Liana C., Zhang, Cuilin, Manson, JoAnn E., Hu, Frank B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631862/
https://www.ncbi.nlm.nih.gov/pubmed/23613602
http://dx.doi.org/10.2337/dc12-0962
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author Song, Yiqing
Wang, Lu
Pittas, Anastassios G.
Del Gobbo, Liana C.
Zhang, Cuilin
Manson, JoAnn E.
Hu, Frank B.
author_facet Song, Yiqing
Wang, Lu
Pittas, Anastassios G.
Del Gobbo, Liana C.
Zhang, Cuilin
Manson, JoAnn E.
Hu, Frank B.
author_sort Song, Yiqing
collection PubMed
description OBJECTIVE: To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: A systematic search of the MEDLINE and Embase databases and a hand search of references from original reports were conducted up to 31 October 2012. Prospective observational studies that assessed the association between blood levels of 25(OH)D and risk of incident type 2 diabetes were included for meta-analysis. DerSimonian and Laird’s random-effects model was used. A quadratic spline regression analysis was used to examine the shape of the association with a generalized least-squares trend test performed for the dose-response relation. RESULTS: A total of 21 prospective studies involving 76,220 participants and 4,996 incident type 2 diabetes cases were included for meta-analysis. Comparing the highest to the lowest category of 25(OH)D levels, the summary relative risk for type 2 diabetes was 0.62 (95% CI 0.54–0.70). A spline regression model showed that higher 25(OH)D levels were monotonically associated with a lower diabetes risk. This inverse association did not differ by sex, duration of follow-up, study sample size, diabetes diagnostic criteria, or 25(OH)D assay method. A linear trend analysis showed that each 10 nmol/L increment in 25(OH)D levels was associated with a 4% lower risk of type 2 diabetes (95% CI 3–6; P for linear trend < 0.0001). CONCLUSIONS: Our meta-analysis showed an inverse and significant association between circulating 25(OH)D levels and risk of type 2 diabetes across a broad range of blood 25(OH)D levels in diverse populations.
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spelling pubmed-36318622014-05-01 Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies Song, Yiqing Wang, Lu Pittas, Anastassios G. Del Gobbo, Liana C. Zhang, Cuilin Manson, JoAnn E. Hu, Frank B. Diabetes Care Meta-Analysis OBJECTIVE: To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: A systematic search of the MEDLINE and Embase databases and a hand search of references from original reports were conducted up to 31 October 2012. Prospective observational studies that assessed the association between blood levels of 25(OH)D and risk of incident type 2 diabetes were included for meta-analysis. DerSimonian and Laird’s random-effects model was used. A quadratic spline regression analysis was used to examine the shape of the association with a generalized least-squares trend test performed for the dose-response relation. RESULTS: A total of 21 prospective studies involving 76,220 participants and 4,996 incident type 2 diabetes cases were included for meta-analysis. Comparing the highest to the lowest category of 25(OH)D levels, the summary relative risk for type 2 diabetes was 0.62 (95% CI 0.54–0.70). A spline regression model showed that higher 25(OH)D levels were monotonically associated with a lower diabetes risk. This inverse association did not differ by sex, duration of follow-up, study sample size, diabetes diagnostic criteria, or 25(OH)D assay method. A linear trend analysis showed that each 10 nmol/L increment in 25(OH)D levels was associated with a 4% lower risk of type 2 diabetes (95% CI 3–6; P for linear trend < 0.0001). CONCLUSIONS: Our meta-analysis showed an inverse and significant association between circulating 25(OH)D levels and risk of type 2 diabetes across a broad range of blood 25(OH)D levels in diverse populations. American Diabetes Association 2013-05 2013-04-13 /pmc/articles/PMC3631862/ /pubmed/23613602 http://dx.doi.org/10.2337/dc12-0962 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Meta-Analysis
Song, Yiqing
Wang, Lu
Pittas, Anastassios G.
Del Gobbo, Liana C.
Zhang, Cuilin
Manson, JoAnn E.
Hu, Frank B.
Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies
title Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies
title_full Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies
title_fullStr Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies
title_full_unstemmed Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies
title_short Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies
title_sort blood 25-hydroxy vitamin d levels and incident type 2 diabetes: a meta-analysis of prospective studies
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631862/
https://www.ncbi.nlm.nih.gov/pubmed/23613602
http://dx.doi.org/10.2337/dc12-0962
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