Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor

A sensitive and selective field-effect transistor (FET) biosensor is demonstrated using vertically-oriented graphene (VG) sheets labeled with gold nanoparticle (NP)-antibody conjugates. VG sheets are directly grown on the sensor electrode using a plasma-enhanced chemical vapor deposition (PECVD) met...

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Autores principales: Mao, Shun, Yu, Kehan, Chang, Jingbo, Steeber, Douglas A., Ocola, Leonidas E., Chen, Junhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631944/
https://www.ncbi.nlm.nih.gov/pubmed/23603871
http://dx.doi.org/10.1038/srep01696
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author Mao, Shun
Yu, Kehan
Chang, Jingbo
Steeber, Douglas A.
Ocola, Leonidas E.
Chen, Junhong
author_facet Mao, Shun
Yu, Kehan
Chang, Jingbo
Steeber, Douglas A.
Ocola, Leonidas E.
Chen, Junhong
author_sort Mao, Shun
collection PubMed
description A sensitive and selective field-effect transistor (FET) biosensor is demonstrated using vertically-oriented graphene (VG) sheets labeled with gold nanoparticle (NP)-antibody conjugates. VG sheets are directly grown on the sensor electrode using a plasma-enhanced chemical vapor deposition (PECVD) method and function as the sensing channel. The protein detection is accomplished through measuring changes in the electrical signal from the FET sensor upon the antibody-antigen binding. The novel biosensor with unique graphene morphology shows high sensitivity (down to ~2 ng/ml or 13 pM) and selectivity towards specific proteins. The PECVD growth of VG presents a one-step and reliable approach to prepare graphene-based electronic biosensors.
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spelling pubmed-36319442013-04-22 Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor Mao, Shun Yu, Kehan Chang, Jingbo Steeber, Douglas A. Ocola, Leonidas E. Chen, Junhong Sci Rep Article A sensitive and selective field-effect transistor (FET) biosensor is demonstrated using vertically-oriented graphene (VG) sheets labeled with gold nanoparticle (NP)-antibody conjugates. VG sheets are directly grown on the sensor electrode using a plasma-enhanced chemical vapor deposition (PECVD) method and function as the sensing channel. The protein detection is accomplished through measuring changes in the electrical signal from the FET sensor upon the antibody-antigen binding. The novel biosensor with unique graphene morphology shows high sensitivity (down to ~2 ng/ml or 13 pM) and selectivity towards specific proteins. The PECVD growth of VG presents a one-step and reliable approach to prepare graphene-based electronic biosensors. Nature Publishing Group 2013-04-22 /pmc/articles/PMC3631944/ /pubmed/23603871 http://dx.doi.org/10.1038/srep01696 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Mao, Shun
Yu, Kehan
Chang, Jingbo
Steeber, Douglas A.
Ocola, Leonidas E.
Chen, Junhong
Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor
title Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor
title_full Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor
title_fullStr Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor
title_full_unstemmed Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor
title_short Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor
title_sort direct growth of vertically-oriented graphene for field-effect transistor biosensor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631944/
https://www.ncbi.nlm.nih.gov/pubmed/23603871
http://dx.doi.org/10.1038/srep01696
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