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V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins

Genetic variation plays a major role in drug response variability. CsA (cyclosporin A), a widely used immunosuppressive agent, is a specific antagonist for FPR1 (formyl peptide receptor 1), which is an important G-protein-coupled chemoattractant receptor in the innate immune system. In order to stud...

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Detalles Bibliográficos
Autores principales:	Zhou, Caihong, Zhou, Yan, Wang, Jia, Feng, Yang, Wang, Haonan, Xue, Jinglun, Chen, Yani, Ye, Richard D., Wang, Ming-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632010/ https://www.ncbi.nlm.nih.gov/pubmed/23373827 http://dx.doi.org/10.1042/BJ20121839

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