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Cytochrome P450 3A4*1B as Pharmacogenomic Predictor of Tacrolimus Pharmacokinetics and Clinical Outcome in the Liver Transplant Recipients

BACKGROUND AND AIMS: Tacrolimus is a macrolide immunosuppressant used for prevention of allograft rejection in organ transplantation and metabolized in the liver and intestine by cytochrome P450 3A4 (CYP3A4) enzyme. A single nucleotide polymorphism (SNP) in the CYP3A4 promoter region has been identi...

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Detalles Bibliográficos
Autores principales:	Albekairy, Abdulkareem, Alkatheri, Abdulmalik, Fujita, Shiro, Hemming, Alan, Howard, Richard, Reed, Alan, Karlix, Janet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632017/ https://www.ncbi.nlm.nih.gov/pubmed/23481136 http://dx.doi.org/10.4103/1319-3767.108484

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