Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells

We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER–PM junctions formed near the leading edge of migrating cell...

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Detalles Bibliográficos
Autores principales: Dingsdale, Hayley, Okeke, Emmanuel, Awais, Muhammad, Haynes, Lee, Criddle, David N., Sutton, Robert, Tepikin, Alexei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632088/
https://www.ncbi.nlm.nih.gov/pubmed/23323887
http://dx.doi.org/10.1042/BJ20121864
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author Dingsdale, Hayley
Okeke, Emmanuel
Awais, Muhammad
Haynes, Lee
Criddle, David N.
Sutton, Robert
Tepikin, Alexei V.
author_facet Dingsdale, Hayley
Okeke, Emmanuel
Awais, Muhammad
Haynes, Lee
Criddle, David N.
Sutton, Robert
Tepikin, Alexei V.
author_sort Dingsdale, Hayley
collection PubMed
description We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER–PM junctions formed near the leading edge of migrating cells (usually within 0.5 μm of polymerized actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution of ER–PM junctions accompanied the tail withdrawal.
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spelling pubmed-36320882013-04-25 Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells Dingsdale, Hayley Okeke, Emmanuel Awais, Muhammad Haynes, Lee Criddle, David N. Sutton, Robert Tepikin, Alexei V. Biochem J Research Article We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER–PM junctions formed near the leading edge of migrating cells (usually within 0.5 μm of polymerized actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution of ER–PM junctions accompanied the tail withdrawal. Portland Press Ltd. 2013-03-14 2013-04-01 /pmc/articles/PMC3632088/ /pubmed/23323887 http://dx.doi.org/10.1042/BJ20121864 Text en © 2013 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dingsdale, Hayley
Okeke, Emmanuel
Awais, Muhammad
Haynes, Lee
Criddle, David N.
Sutton, Robert
Tepikin, Alexei V.
Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells
title Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells
title_full Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells
title_fullStr Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells
title_full_unstemmed Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells
title_short Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells
title_sort saltatory formation, sliding and dissolution of er–pm junctions in migrating cancer cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632088/
https://www.ncbi.nlm.nih.gov/pubmed/23323887
http://dx.doi.org/10.1042/BJ20121864
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