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Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes

During the CD4(−)CD8(−) (DN) stage of T-cell development, RAG-dependent DNA breaks and V(D)J recombination occur at three T-cell receptor (TCR) loci: TCRβ, TCRγ and TCRδ. During this stage, abnormal trans-rearrangements also take place between TCR loci, occurring at increased frequency in absence of...

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Detalles Bibliográficos
Autores principales:	Bowen, Steven, Wangsa, Darawalee, Ried, Thomas, Livak, Ferenc, Hodes, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632137/ https://www.ncbi.nlm.nih.gov/pubmed/23470994 http://dx.doi.org/10.1093/nar/gkt154

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