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SIMPL Enhancement of Tumor Necrosis Factor-α Dependent p65-MED1 Complex Formation Is Required for Mammalian Hematopoietic Stem and Progenitor Cell Function

Significant insight into the signaling pathways leading to activation of the Rel transcription factor family, collectively termed NF-κB, has been gained. Less well understood is how subsets of NF-κB-dependent genes are regulated in a signal specific manner. The SIMPL protein (signaling molecule that...

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Detalles Bibliográficos
Autores principales:	Zhao, Weina, Breese, Erin, Bowers, Allison, Hoggatt, Jonathan, Pelus, Louis M., Broxmeyer, Hal E., Goebl, Mark, Harrington, Maureen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632537/ https://www.ncbi.nlm.nih.gov/pubmed/23630580 http://dx.doi.org/10.1371/journal.pone.0061123

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