FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native cytokine, we generated bispecific Avimer polypeptides that bind with high affinity and specificity to one of the receptor and coreceptor pairs...

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Detalles Bibliográficos
Autores principales: Smith, Richard, Duguay, Amy, Bakker, Alice, Li, Peng, Weiszmann, Jennifer, Thomas, Melissa R., Alba, Benjamin M., Wu, Xinle, Gupte, Jamila, Yang, Li, Stevens, Jennitte, Hamburger, Agnes, Smith, Stephen, Chen, Jiyun, Komorowski, Renee, Moore, Kevin W., Véniant, Murielle M., Li, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632592/
https://www.ncbi.nlm.nih.gov/pubmed/23630589
http://dx.doi.org/10.1371/journal.pone.0061432

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