Pleiotrophin Gene Therapy for Peripheral Ischemia: Evaluation of Full-Length and Truncated Gene Variants

Pleiotrophin (PTN) is a growth factor with both pro-angiogenic and limited pro-tumorigenic activity. We evaluated the potential for PTN to be used for safe angiogenic gene therapy using the full length gene and a truncated gene variant lacking the domain implicated in tumorigenesis. Mouse myoblasts...

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Detalles Bibliográficos
Autores principales: Fang, Qizhi, Mok, Pamela Y., Thomas, Anila E., Haddad, Daniel J., Saini, Shereen A., Clifford, Brian T., Kapasi, Neel K., Danforth, Olivia M., Usui, Minako, Ye, Weisheng, Luu, Emmy, Sharma, Rikki, Bartel, Maya J., Pathmanabhan, Jeremy A., Ang, Andrew A. S., Sievers, Richard E., Lee, Randall J., Springer, Matthew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632611/
https://www.ncbi.nlm.nih.gov/pubmed/23630585
http://dx.doi.org/10.1371/journal.pone.0061413

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