Methylation muscles into transcription factor silencing

The transcription factor MyoD is a master regulator of skeletal muscle differentiation. The finding that G9a, an enzyme principally involved in histone H3 lysine 9 di-methylation (H3K9me2), methylates MyoD, identifies previously unappreciated mechanisms by which chromatin modifiers regulate the tran...

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Detalles Bibliográficos
Autores principales: Bharathy, Narendra, Taneja, Reshma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632615/
https://www.ncbi.nlm.nih.gov/pubmed/22771996
http://dx.doi.org/10.4161/trns.20914
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author Bharathy, Narendra
Taneja, Reshma
author_facet Bharathy, Narendra
Taneja, Reshma
author_sort Bharathy, Narendra
collection PubMed
description The transcription factor MyoD is a master regulator of skeletal muscle differentiation. The finding that G9a, an enzyme principally involved in histone H3 lysine 9 di-methylation (H3K9me2), methylates MyoD, identifies previously unappreciated mechanisms by which chromatin modifiers regulate the transcriptional activity of non-histone substrates to control cellular differentiation programs.
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spelling pubmed-36326152013-04-25 Methylation muscles into transcription factor silencing Bharathy, Narendra Taneja, Reshma Transcription Point of View The transcription factor MyoD is a master regulator of skeletal muscle differentiation. The finding that G9a, an enzyme principally involved in histone H3 lysine 9 di-methylation (H3K9me2), methylates MyoD, identifies previously unappreciated mechanisms by which chromatin modifiers regulate the transcriptional activity of non-histone substrates to control cellular differentiation programs. Landes Bioscience 2012-09-01 2012-09-01 /pmc/articles/PMC3632615/ /pubmed/22771996 http://dx.doi.org/10.4161/trns.20914 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Point of View
Bharathy, Narendra
Taneja, Reshma
Methylation muscles into transcription factor silencing
title Methylation muscles into transcription factor silencing
title_full Methylation muscles into transcription factor silencing
title_fullStr Methylation muscles into transcription factor silencing
title_full_unstemmed Methylation muscles into transcription factor silencing
title_short Methylation muscles into transcription factor silencing
title_sort methylation muscles into transcription factor silencing
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632615/
https://www.ncbi.nlm.nih.gov/pubmed/22771996
http://dx.doi.org/10.4161/trns.20914
work_keys_str_mv AT bharathynarendra methylationmusclesintotranscriptionfactorsilencing
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