How p53 wields the scales of fate: Arrest or death?

Understanding how the tumor suppressor p53 induces cell cycle arrest or apoptosis is critical for developing chemotherapeutic strategies. We have generated targeted transgenic reporter mice with which we can study p53 activity at specific promoters, and propose a model in which p53 protein conformat...

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Detalles Bibliográficos
Autores principales: Goh, Amanda M., Lane, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632620/
https://www.ncbi.nlm.nih.gov/pubmed/22885979
http://dx.doi.org/10.4161/trns.21297
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author Goh, Amanda M.
Lane, David P.
author_facet Goh, Amanda M.
Lane, David P.
author_sort Goh, Amanda M.
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description Understanding how the tumor suppressor p53 induces cell cycle arrest or apoptosis is critical for developing chemotherapeutic strategies. We have generated targeted transgenic reporter mice with which we can study p53 activity at specific promoters, and propose a model in which p53 protein conformation is key to target gene selection.
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spelling pubmed-36326202013-04-25 How p53 wields the scales of fate: Arrest or death? Goh, Amanda M. Lane, David P. Transcription Point of View Understanding how the tumor suppressor p53 induces cell cycle arrest or apoptosis is critical for developing chemotherapeutic strategies. We have generated targeted transgenic reporter mice with which we can study p53 activity at specific promoters, and propose a model in which p53 protein conformation is key to target gene selection. Landes Bioscience 2012-09-01 2012-09-01 /pmc/articles/PMC3632620/ /pubmed/22885979 http://dx.doi.org/10.4161/trns.21297 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Point of View
Goh, Amanda M.
Lane, David P.
How p53 wields the scales of fate: Arrest or death?
title How p53 wields the scales of fate: Arrest or death?
title_full How p53 wields the scales of fate: Arrest or death?
title_fullStr How p53 wields the scales of fate: Arrest or death?
title_full_unstemmed How p53 wields the scales of fate: Arrest or death?
title_short How p53 wields the scales of fate: Arrest or death?
title_sort how p53 wields the scales of fate: arrest or death?
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632620/
https://www.ncbi.nlm.nih.gov/pubmed/22885979
http://dx.doi.org/10.4161/trns.21297
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