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Upregulation of epidermal growth factor receptor 4 in oral leukoplakia

In the present study, we investigate the expression profile of the epidermal growth factor receptor family, which comprises EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia (LP). The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were m...

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Autores principales: Kobayashi, Hiroshi, Kumagai, Kenichi, Gotoh, Akito, Eguchi, Takanori, Yamada, Hiroyuki, Hamada, Yoshiki, Suzuki, Satsuki, Suzuki, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632759/
https://www.ncbi.nlm.nih.gov/pubmed/23492901
http://dx.doi.org/10.1038/ijos.2013.10
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author Kobayashi, Hiroshi
Kumagai, Kenichi
Gotoh, Akito
Eguchi, Takanori
Yamada, Hiroyuki
Hamada, Yoshiki
Suzuki, Satsuki
Suzuki, Ryuji
author_facet Kobayashi, Hiroshi
Kumagai, Kenichi
Gotoh, Akito
Eguchi, Takanori
Yamada, Hiroyuki
Hamada, Yoshiki
Suzuki, Satsuki
Suzuki, Ryuji
author_sort Kobayashi, Hiroshi
collection PubMed
description In the present study, we investigate the expression profile of the epidermal growth factor receptor family, which comprises EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia (LP). The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus (OLP) and normal oral mucosa (NOM) from 14 healthy donors by real-time polymerase chain reaction (PCR) and immunohistochemistry. Synchronous mRNA coexpression of ErbB1, ErbB2, ErbB3 and ErbB4 was detected in LP lesions. Out of the receptors, only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM tissues. These were strongly expressed by epithelial keratinocytes in LP lesions, as shown by immunohistochemistry. Regarding the ligands, the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM tissues. Therefore, enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP.
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spelling pubmed-36327592013-04-23 Upregulation of epidermal growth factor receptor 4 in oral leukoplakia Kobayashi, Hiroshi Kumagai, Kenichi Gotoh, Akito Eguchi, Takanori Yamada, Hiroyuki Hamada, Yoshiki Suzuki, Satsuki Suzuki, Ryuji Int J Oral Sci Original Article In the present study, we investigate the expression profile of the epidermal growth factor receptor family, which comprises EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia (LP). The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus (OLP) and normal oral mucosa (NOM) from 14 healthy donors by real-time polymerase chain reaction (PCR) and immunohistochemistry. Synchronous mRNA coexpression of ErbB1, ErbB2, ErbB3 and ErbB4 was detected in LP lesions. Out of the receptors, only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM tissues. These were strongly expressed by epithelial keratinocytes in LP lesions, as shown by immunohistochemistry. Regarding the ligands, the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM tissues. Therefore, enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP. Nature Publishing Group 2013-04 2013-03-15 /pmc/articles/PMC3632759/ /pubmed/23492901 http://dx.doi.org/10.1038/ijos.2013.10 Text en Copyright © 2013 West China School of Stomatology http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Kobayashi, Hiroshi
Kumagai, Kenichi
Gotoh, Akito
Eguchi, Takanori
Yamada, Hiroyuki
Hamada, Yoshiki
Suzuki, Satsuki
Suzuki, Ryuji
Upregulation of epidermal growth factor receptor 4 in oral leukoplakia
title Upregulation of epidermal growth factor receptor 4 in oral leukoplakia
title_full Upregulation of epidermal growth factor receptor 4 in oral leukoplakia
title_fullStr Upregulation of epidermal growth factor receptor 4 in oral leukoplakia
title_full_unstemmed Upregulation of epidermal growth factor receptor 4 in oral leukoplakia
title_short Upregulation of epidermal growth factor receptor 4 in oral leukoplakia
title_sort upregulation of epidermal growth factor receptor 4 in oral leukoplakia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632759/
https://www.ncbi.nlm.nih.gov/pubmed/23492901
http://dx.doi.org/10.1038/ijos.2013.10
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