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Upregulation of epidermal growth factor receptor 4 in oral leukoplakia
In the present study, we investigate the expression profile of the epidermal growth factor receptor family, which comprises EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia (LP). The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were m...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632759/ https://www.ncbi.nlm.nih.gov/pubmed/23492901 http://dx.doi.org/10.1038/ijos.2013.10 |
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author | Kobayashi, Hiroshi Kumagai, Kenichi Gotoh, Akito Eguchi, Takanori Yamada, Hiroyuki Hamada, Yoshiki Suzuki, Satsuki Suzuki, Ryuji |
author_facet | Kobayashi, Hiroshi Kumagai, Kenichi Gotoh, Akito Eguchi, Takanori Yamada, Hiroyuki Hamada, Yoshiki Suzuki, Satsuki Suzuki, Ryuji |
author_sort | Kobayashi, Hiroshi |
collection | PubMed |
description | In the present study, we investigate the expression profile of the epidermal growth factor receptor family, which comprises EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia (LP). The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus (OLP) and normal oral mucosa (NOM) from 14 healthy donors by real-time polymerase chain reaction (PCR) and immunohistochemistry. Synchronous mRNA coexpression of ErbB1, ErbB2, ErbB3 and ErbB4 was detected in LP lesions. Out of the receptors, only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM tissues. These were strongly expressed by epithelial keratinocytes in LP lesions, as shown by immunohistochemistry. Regarding the ligands, the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM tissues. Therefore, enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP. |
format | Online Article Text |
id | pubmed-3632759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-36327592013-04-23 Upregulation of epidermal growth factor receptor 4 in oral leukoplakia Kobayashi, Hiroshi Kumagai, Kenichi Gotoh, Akito Eguchi, Takanori Yamada, Hiroyuki Hamada, Yoshiki Suzuki, Satsuki Suzuki, Ryuji Int J Oral Sci Original Article In the present study, we investigate the expression profile of the epidermal growth factor receptor family, which comprises EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia (LP). The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus (OLP) and normal oral mucosa (NOM) from 14 healthy donors by real-time polymerase chain reaction (PCR) and immunohistochemistry. Synchronous mRNA coexpression of ErbB1, ErbB2, ErbB3 and ErbB4 was detected in LP lesions. Out of the receptors, only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM tissues. These were strongly expressed by epithelial keratinocytes in LP lesions, as shown by immunohistochemistry. Regarding the ligands, the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM tissues. Therefore, enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP. Nature Publishing Group 2013-04 2013-03-15 /pmc/articles/PMC3632759/ /pubmed/23492901 http://dx.doi.org/10.1038/ijos.2013.10 Text en Copyright © 2013 West China School of Stomatology http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Original Article Kobayashi, Hiroshi Kumagai, Kenichi Gotoh, Akito Eguchi, Takanori Yamada, Hiroyuki Hamada, Yoshiki Suzuki, Satsuki Suzuki, Ryuji Upregulation of epidermal growth factor receptor 4 in oral leukoplakia |
title | Upregulation of epidermal growth factor receptor 4 in oral leukoplakia |
title_full | Upregulation of epidermal growth factor receptor 4 in oral leukoplakia |
title_fullStr | Upregulation of epidermal growth factor receptor 4 in oral leukoplakia |
title_full_unstemmed | Upregulation of epidermal growth factor receptor 4 in oral leukoplakia |
title_short | Upregulation of epidermal growth factor receptor 4 in oral leukoplakia |
title_sort | upregulation of epidermal growth factor receptor 4 in oral leukoplakia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632759/ https://www.ncbi.nlm.nih.gov/pubmed/23492901 http://dx.doi.org/10.1038/ijos.2013.10 |
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