Cargando…
Analytical results on the Beauchemin model of lymphocyte migration
The Beauchemin model is a simple particle-based description of stochastic lymphocyte migration in tissue, which has been successfully applied to studying immunological questions. In addition to being easy to implement, the model is also to a large extent mathematically tractable. This article provid...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633013/ https://www.ncbi.nlm.nih.gov/pubmed/23734948 http://dx.doi.org/10.1186/1471-2105-14-S6-S10 |
_version_ | 1782266928949100544 |
---|---|
author | Textor, Johannes Sinn, Mathieu de Boer, Rob J |
author_facet | Textor, Johannes Sinn, Mathieu de Boer, Rob J |
author_sort | Textor, Johannes |
collection | PubMed |
description | The Beauchemin model is a simple particle-based description of stochastic lymphocyte migration in tissue, which has been successfully applied to studying immunological questions. In addition to being easy to implement, the model is also to a large extent mathematically tractable. This article provides a comprehensive overview of both existing and new analytical results on the Beauchemin model within a common mathematical framework. Specifically, we derive the motility coefficient, the mean square displacement, and the confinement ratio, and discuss four different methods for simulating biased migration of pre-defined speed. The results provide new insight into published studies and a reference point for future research based on this simple and popular lymphocyte migration model. |
format | Online Article Text |
id | pubmed-3633013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36330132013-04-25 Analytical results on the Beauchemin model of lymphocyte migration Textor, Johannes Sinn, Mathieu de Boer, Rob J BMC Bioinformatics Proceedings The Beauchemin model is a simple particle-based description of stochastic lymphocyte migration in tissue, which has been successfully applied to studying immunological questions. In addition to being easy to implement, the model is also to a large extent mathematically tractable. This article provides a comprehensive overview of both existing and new analytical results on the Beauchemin model within a common mathematical framework. Specifically, we derive the motility coefficient, the mean square displacement, and the confinement ratio, and discuss four different methods for simulating biased migration of pre-defined speed. The results provide new insight into published studies and a reference point for future research based on this simple and popular lymphocyte migration model. BioMed Central 2013-04-17 /pmc/articles/PMC3633013/ /pubmed/23734948 http://dx.doi.org/10.1186/1471-2105-14-S6-S10 Text en Copyright © 2012 Textor et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Proceedings Textor, Johannes Sinn, Mathieu de Boer, Rob J Analytical results on the Beauchemin model of lymphocyte migration |
title | Analytical results on the Beauchemin model of lymphocyte migration |
title_full | Analytical results on the Beauchemin model of lymphocyte migration |
title_fullStr | Analytical results on the Beauchemin model of lymphocyte migration |
title_full_unstemmed | Analytical results on the Beauchemin model of lymphocyte migration |
title_short | Analytical results on the Beauchemin model of lymphocyte migration |
title_sort | analytical results on the beauchemin model of lymphocyte migration |
topic | Proceedings |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633013/ https://www.ncbi.nlm.nih.gov/pubmed/23734948 http://dx.doi.org/10.1186/1471-2105-14-S6-S10 |
work_keys_str_mv | AT textorjohannes analyticalresultsonthebeaucheminmodeloflymphocytemigration AT sinnmathieu analyticalresultsonthebeaucheminmodeloflymphocytemigration AT deboerrobj analyticalresultsonthebeaucheminmodeloflymphocytemigration |