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Analytical results on the Beauchemin model of lymphocyte migration

The Beauchemin model is a simple particle-based description of stochastic lymphocyte migration in tissue, which has been successfully applied to studying immunological questions. In addition to being easy to implement, the model is also to a large extent mathematically tractable. This article provid...

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Detalles Bibliográficos
Autores principales: Textor, Johannes, Sinn, Mathieu, de Boer, Rob J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633013/
https://www.ncbi.nlm.nih.gov/pubmed/23734948
http://dx.doi.org/10.1186/1471-2105-14-S6-S10
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author Textor, Johannes
Sinn, Mathieu
de Boer, Rob J
author_facet Textor, Johannes
Sinn, Mathieu
de Boer, Rob J
author_sort Textor, Johannes
collection PubMed
description The Beauchemin model is a simple particle-based description of stochastic lymphocyte migration in tissue, which has been successfully applied to studying immunological questions. In addition to being easy to implement, the model is also to a large extent mathematically tractable. This article provides a comprehensive overview of both existing and new analytical results on the Beauchemin model within a common mathematical framework. Specifically, we derive the motility coefficient, the mean square displacement, and the confinement ratio, and discuss four different methods for simulating biased migration of pre-defined speed. The results provide new insight into published studies and a reference point for future research based on this simple and popular lymphocyte migration model.
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spelling pubmed-36330132013-04-25 Analytical results on the Beauchemin model of lymphocyte migration Textor, Johannes Sinn, Mathieu de Boer, Rob J BMC Bioinformatics Proceedings The Beauchemin model is a simple particle-based description of stochastic lymphocyte migration in tissue, which has been successfully applied to studying immunological questions. In addition to being easy to implement, the model is also to a large extent mathematically tractable. This article provides a comprehensive overview of both existing and new analytical results on the Beauchemin model within a common mathematical framework. Specifically, we derive the motility coefficient, the mean square displacement, and the confinement ratio, and discuss four different methods for simulating biased migration of pre-defined speed. The results provide new insight into published studies and a reference point for future research based on this simple and popular lymphocyte migration model. BioMed Central 2013-04-17 /pmc/articles/PMC3633013/ /pubmed/23734948 http://dx.doi.org/10.1186/1471-2105-14-S6-S10 Text en Copyright © 2012 Textor et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Textor, Johannes
Sinn, Mathieu
de Boer, Rob J
Analytical results on the Beauchemin model of lymphocyte migration
title Analytical results on the Beauchemin model of lymphocyte migration
title_full Analytical results on the Beauchemin model of lymphocyte migration
title_fullStr Analytical results on the Beauchemin model of lymphocyte migration
title_full_unstemmed Analytical results on the Beauchemin model of lymphocyte migration
title_short Analytical results on the Beauchemin model of lymphocyte migration
title_sort analytical results on the beauchemin model of lymphocyte migration
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633013/
https://www.ncbi.nlm.nih.gov/pubmed/23734948
http://dx.doi.org/10.1186/1471-2105-14-S6-S10
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