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Is High IQ Protective Against Cognitive Dysfunction in Narcoleptic Patients?

BACKGROUND AND PURPOSE: The aims of this study were to elucidate the cognitive functions of narcoleptics and determine whether intelligence protects against cognitive dysfunction and depressive mood in these patients. METHODS: Sixty-six subjects (33 narcoleptics, 33 controls) were administered a bat...

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Autores principales: Yoon, So-Mee, Joo, Eun Yeon, Kim, Ji Young, Hwang, Kyoung Jin, Hong, Seung Bong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633189/
https://www.ncbi.nlm.nih.gov/pubmed/23626650
http://dx.doi.org/10.3988/jcn.2013.9.2.118
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author Yoon, So-Mee
Joo, Eun Yeon
Kim, Ji Young
Hwang, Kyoung Jin
Hong, Seung Bong
author_facet Yoon, So-Mee
Joo, Eun Yeon
Kim, Ji Young
Hwang, Kyoung Jin
Hong, Seung Bong
author_sort Yoon, So-Mee
collection PubMed
description BACKGROUND AND PURPOSE: The aims of this study were to elucidate the cognitive functions of narcoleptics and determine whether intelligence protects against cognitive dysfunction and depressive mood in these patients. METHODS: Sixty-six subjects (33 narcoleptics, 33 controls) were administered a battery of neuropsychological tests and an individual standardized intelligence test. The cognitive functions of the narcoleptic patients and the healthy controls were compared, as were those of high-IQ and mid-to-low-IQ narcoleptic patients. RESULTS: Narcoleptics exhibited significantly lower scores in the Corsi Block-Tapping Test forward and backward, and the digit symbol tests, and significantly higher Beck Depression Inventory scores than the controls. However, verbal attention, verbal-visual long-term memory, and executive function task scores did not differ significantly between patients and controls. The mid-to-low-IQ patient group had lower mean digit span backward test, phonemic and semantic fluency Controlled Oral Word Association Test and Korean version of the Boston Naming Test scores, and a higher total score and general depressive symptoms subscales Beck Depression Inventory score than the high-IQ patient group. However, controls exhibited no IQ-related differences in cognitive performance or depressive mood. Patients in the high-IQ group exhibited impaired visual attention and working memory as compared with controls. CONCLUSIONS: The findings of the present study show that narcolepsy patients have deficits in visual attention and visual working memory, and tend to feel more general depressive symptoms but not somatic symptoms than their control, nonnarcoleptic counterparts. In addition, it appears that higher intelligence protects against cognitive dysfunction and depressive mood.
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spelling pubmed-36331892013-04-26 Is High IQ Protective Against Cognitive Dysfunction in Narcoleptic Patients? Yoon, So-Mee Joo, Eun Yeon Kim, Ji Young Hwang, Kyoung Jin Hong, Seung Bong J Clin Neurol Original Article BACKGROUND AND PURPOSE: The aims of this study were to elucidate the cognitive functions of narcoleptics and determine whether intelligence protects against cognitive dysfunction and depressive mood in these patients. METHODS: Sixty-six subjects (33 narcoleptics, 33 controls) were administered a battery of neuropsychological tests and an individual standardized intelligence test. The cognitive functions of the narcoleptic patients and the healthy controls were compared, as were those of high-IQ and mid-to-low-IQ narcoleptic patients. RESULTS: Narcoleptics exhibited significantly lower scores in the Corsi Block-Tapping Test forward and backward, and the digit symbol tests, and significantly higher Beck Depression Inventory scores than the controls. However, verbal attention, verbal-visual long-term memory, and executive function task scores did not differ significantly between patients and controls. The mid-to-low-IQ patient group had lower mean digit span backward test, phonemic and semantic fluency Controlled Oral Word Association Test and Korean version of the Boston Naming Test scores, and a higher total score and general depressive symptoms subscales Beck Depression Inventory score than the high-IQ patient group. However, controls exhibited no IQ-related differences in cognitive performance or depressive mood. Patients in the high-IQ group exhibited impaired visual attention and working memory as compared with controls. CONCLUSIONS: The findings of the present study show that narcolepsy patients have deficits in visual attention and visual working memory, and tend to feel more general depressive symptoms but not somatic symptoms than their control, nonnarcoleptic counterparts. In addition, it appears that higher intelligence protects against cognitive dysfunction and depressive mood. Korean Neurological Association 2013-04 2013-04-04 /pmc/articles/PMC3633189/ /pubmed/23626650 http://dx.doi.org/10.3988/jcn.2013.9.2.118 Text en Copyright © 2013 Korean Neurological Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoon, So-Mee
Joo, Eun Yeon
Kim, Ji Young
Hwang, Kyoung Jin
Hong, Seung Bong
Is High IQ Protective Against Cognitive Dysfunction in Narcoleptic Patients?
title Is High IQ Protective Against Cognitive Dysfunction in Narcoleptic Patients?
title_full Is High IQ Protective Against Cognitive Dysfunction in Narcoleptic Patients?
title_fullStr Is High IQ Protective Against Cognitive Dysfunction in Narcoleptic Patients?
title_full_unstemmed Is High IQ Protective Against Cognitive Dysfunction in Narcoleptic Patients?
title_short Is High IQ Protective Against Cognitive Dysfunction in Narcoleptic Patients?
title_sort is high iq protective against cognitive dysfunction in narcoleptic patients?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633189/
https://www.ncbi.nlm.nih.gov/pubmed/23626650
http://dx.doi.org/10.3988/jcn.2013.9.2.118
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