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Hypolipidemia in Patients with Amyotrophic Lateral Sclerosis: A Possible Gender Difference?
BACKGROUND AND PURPOSE: We compared the levels of serum lipid, protein, and glucose between patients with amyotrophic lateral sclerosis (ALS) and healthy controls. METHODS: The serum levels of lipids [including triglycerides, cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurological Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633190/ https://www.ncbi.nlm.nih.gov/pubmed/23626651 http://dx.doi.org/10.3988/jcn.2013.9.2.125 |
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author | Yang, Ji Won Kim, Sung-Min Kim, Hee-Juang Kim, Jee-Eun Park, Kyung Seok Kim, Seung-Hyun Lee, Kwang-Woo Sung, Jung-Joon |
author_facet | Yang, Ji Won Kim, Sung-Min Kim, Hee-Juang Kim, Jee-Eun Park, Kyung Seok Kim, Seung-Hyun Lee, Kwang-Woo Sung, Jung-Joon |
author_sort | Yang, Ji Won |
collection | PubMed |
description | BACKGROUND AND PURPOSE: We compared the levels of serum lipid, protein, and glucose between patients with amyotrophic lateral sclerosis (ALS) and healthy controls. METHODS: The serum levels of lipids [including triglycerides, cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)], protein, and glucose of 95 patients with ALS (60 men) were compared with those of 99 age- and sex-matched healthy controls (64 men). Both groups had normal dietary intakes. RESULTS: Total cholesterol (p=0.004), LDL (p=0.040), triglyceride (p=0.025), and protein (p=0.010) levels, and LDL/HDL ratios (p<0.001) in men with ALS were significantly lower than those in their control counterparts. There were no such significant differences in these parameters between female patients with ALS and female controls. CONCLUSIONS: The serum levels of lipid and protein were significantly lower in male patients with ALS than in the male controls. Since we controlled for the confounding effects of dietary intake, hypolipidemia in ALS might be associated with the pathophysiology of the disease rather than being the result of the decreased dietary intake in ALS patients. Metabolic demand might increase in ALS, and it may be affected by gender. |
format | Online Article Text |
id | pubmed-3633190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-36331902013-04-26 Hypolipidemia in Patients with Amyotrophic Lateral Sclerosis: A Possible Gender Difference? Yang, Ji Won Kim, Sung-Min Kim, Hee-Juang Kim, Jee-Eun Park, Kyung Seok Kim, Seung-Hyun Lee, Kwang-Woo Sung, Jung-Joon J Clin Neurol Original Article BACKGROUND AND PURPOSE: We compared the levels of serum lipid, protein, and glucose between patients with amyotrophic lateral sclerosis (ALS) and healthy controls. METHODS: The serum levels of lipids [including triglycerides, cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)], protein, and glucose of 95 patients with ALS (60 men) were compared with those of 99 age- and sex-matched healthy controls (64 men). Both groups had normal dietary intakes. RESULTS: Total cholesterol (p=0.004), LDL (p=0.040), triglyceride (p=0.025), and protein (p=0.010) levels, and LDL/HDL ratios (p<0.001) in men with ALS were significantly lower than those in their control counterparts. There were no such significant differences in these parameters between female patients with ALS and female controls. CONCLUSIONS: The serum levels of lipid and protein were significantly lower in male patients with ALS than in the male controls. Since we controlled for the confounding effects of dietary intake, hypolipidemia in ALS might be associated with the pathophysiology of the disease rather than being the result of the decreased dietary intake in ALS patients. Metabolic demand might increase in ALS, and it may be affected by gender. Korean Neurological Association 2013-04 2013-04-04 /pmc/articles/PMC3633190/ /pubmed/23626651 http://dx.doi.org/10.3988/jcn.2013.9.2.125 Text en Copyright © 2013 Korean Neurological Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yang, Ji Won Kim, Sung-Min Kim, Hee-Juang Kim, Jee-Eun Park, Kyung Seok Kim, Seung-Hyun Lee, Kwang-Woo Sung, Jung-Joon Hypolipidemia in Patients with Amyotrophic Lateral Sclerosis: A Possible Gender Difference? |
title | Hypolipidemia in Patients with Amyotrophic Lateral Sclerosis: A Possible Gender Difference? |
title_full | Hypolipidemia in Patients with Amyotrophic Lateral Sclerosis: A Possible Gender Difference? |
title_fullStr | Hypolipidemia in Patients with Amyotrophic Lateral Sclerosis: A Possible Gender Difference? |
title_full_unstemmed | Hypolipidemia in Patients with Amyotrophic Lateral Sclerosis: A Possible Gender Difference? |
title_short | Hypolipidemia in Patients with Amyotrophic Lateral Sclerosis: A Possible Gender Difference? |
title_sort | hypolipidemia in patients with amyotrophic lateral sclerosis: a possible gender difference? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633190/ https://www.ncbi.nlm.nih.gov/pubmed/23626651 http://dx.doi.org/10.3988/jcn.2013.9.2.125 |
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