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The Coexistence of Myasthenia Gravis and Myotonic Dystrophy Type 2 in a Single Patient

BACKGROUND: Myasthenia gravis (MG) and myotonic dystrophy type 2 (DM2) are rare disorders individually, and their coexistence in the same patient is very rare. We present a patient in which these two diseases coexisted. CASE REPORT: The patient complained of diplopia, fluctuating limb weakness, and...

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Autores principales: Nikolic, Ana, Rakocevic Stojanovic, Vidosava, Romac, Stanka, Savic, Dusanka, Basta, Ivana, Lavrnic, Dragana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633191/
https://www.ncbi.nlm.nih.gov/pubmed/23626652
http://dx.doi.org/10.3988/jcn.2013.9.2.130
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author Nikolic, Ana
Rakocevic Stojanovic, Vidosava
Romac, Stanka
Savic, Dusanka
Basta, Ivana
Lavrnic, Dragana
author_facet Nikolic, Ana
Rakocevic Stojanovic, Vidosava
Romac, Stanka
Savic, Dusanka
Basta, Ivana
Lavrnic, Dragana
author_sort Nikolic, Ana
collection PubMed
description BACKGROUND: Myasthenia gravis (MG) and myotonic dystrophy type 2 (DM2) are rare disorders individually, and their coexistence in the same patient is very rare. We present a patient in which these two diseases coexisted. CASE REPORT: The patient complained of diplopia, fluctuating limb weakness, and difficulties in swallowing and speaking. A neurological examination revealed diplopia, facial, weakness of the neck and proximal limb muscles, dysphagia, dysphonia, and myotonia. The patient's mother had DM2 and her maternal grandfather had cataracts. MG was confirmed in our patient by positive results for neostigmine and a repetitive nerve stimulation test, and elevated serum anti-acetylcholine-receptor antibodies, while DM2 was confirmed by electromyography and genetic testing. The patient improved remarkably after treatment with anticholinesterases, corticosteroids, and azathioprine. CONCLUSIONS: This is the second reported case of the coexistence of DM2 and MG in the same patient. Since the symptoms of these two diseases overlap it is very important to keep in mind the possibility of their coexistence, so that MG is not overlooked in patients with a family history of myotonic dystrophy.
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spelling pubmed-36331912013-04-26 The Coexistence of Myasthenia Gravis and Myotonic Dystrophy Type 2 in a Single Patient Nikolic, Ana Rakocevic Stojanovic, Vidosava Romac, Stanka Savic, Dusanka Basta, Ivana Lavrnic, Dragana J Clin Neurol Case Report BACKGROUND: Myasthenia gravis (MG) and myotonic dystrophy type 2 (DM2) are rare disorders individually, and their coexistence in the same patient is very rare. We present a patient in which these two diseases coexisted. CASE REPORT: The patient complained of diplopia, fluctuating limb weakness, and difficulties in swallowing and speaking. A neurological examination revealed diplopia, facial, weakness of the neck and proximal limb muscles, dysphagia, dysphonia, and myotonia. The patient's mother had DM2 and her maternal grandfather had cataracts. MG was confirmed in our patient by positive results for neostigmine and a repetitive nerve stimulation test, and elevated serum anti-acetylcholine-receptor antibodies, while DM2 was confirmed by electromyography and genetic testing. The patient improved remarkably after treatment with anticholinesterases, corticosteroids, and azathioprine. CONCLUSIONS: This is the second reported case of the coexistence of DM2 and MG in the same patient. Since the symptoms of these two diseases overlap it is very important to keep in mind the possibility of their coexistence, so that MG is not overlooked in patients with a family history of myotonic dystrophy. Korean Neurological Association 2013-04 2013-04-04 /pmc/articles/PMC3633191/ /pubmed/23626652 http://dx.doi.org/10.3988/jcn.2013.9.2.130 Text en Copyright © 2013 Korean Neurological Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nikolic, Ana
Rakocevic Stojanovic, Vidosava
Romac, Stanka
Savic, Dusanka
Basta, Ivana
Lavrnic, Dragana
The Coexistence of Myasthenia Gravis and Myotonic Dystrophy Type 2 in a Single Patient
title The Coexistence of Myasthenia Gravis and Myotonic Dystrophy Type 2 in a Single Patient
title_full The Coexistence of Myasthenia Gravis and Myotonic Dystrophy Type 2 in a Single Patient
title_fullStr The Coexistence of Myasthenia Gravis and Myotonic Dystrophy Type 2 in a Single Patient
title_full_unstemmed The Coexistence of Myasthenia Gravis and Myotonic Dystrophy Type 2 in a Single Patient
title_short The Coexistence of Myasthenia Gravis and Myotonic Dystrophy Type 2 in a Single Patient
title_sort coexistence of myasthenia gravis and myotonic dystrophy type 2 in a single patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633191/
https://www.ncbi.nlm.nih.gov/pubmed/23626652
http://dx.doi.org/10.3988/jcn.2013.9.2.130
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