Cargando…

The Puzzling Case of Hyperexcitability in Amyotrophic Lateral Sclerosis

The development of hyperexcitability in amyotrophic lateral sclerosis (ALS) is a well-known phenomenon. Despite controversy as to the underlying mechanisms, cortical hyperexcitability appears to be closely related to the interplay between excitatory corticomotoneurons and inhibitory interneurons. Hy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bae, Jong Seok, Simon, Neil G., Menon, Parvathi, Vucic, Steve, Kiernan, Matthew C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Neurological Association 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633193/ https://www.ncbi.nlm.nih.gov/pubmed/23626643 http://dx.doi.org/10.3988/jcn.2013.9.2.65

Ejemplares similares

Cortical Dysfunction Underlies the Development of the Split-Hand in Amyotrophic Lateral Sclerosis
por: Menon, Parvathi, et al.
Publicado: (2014)

Regional motor cortex dysfunction in amyotrophic lateral sclerosis
por: Menon, Parvathi, et al.
Publicado: (2019)

Cortical hyperexcitability evolves with disease progression in ALS
por: Menon, Parvathi, et al.
Publicado: (2020)

Functional Biomarkers for Amyotrophic Lateral Sclerosis
por: Huynh, William, et al.
Publicado: (2019)

Quantifying Disease Progression in Amyotrophic Lateral Sclerosis
por: Simon, Neil G, et al.
Publicado: (2014)

Neuronal Hyperexcitability and Free Radical Toxicity in Amyotrophic Lateral Sclerosis: Established and Future Targets
por: Shibuya, Kazumoto, et al.
Publicado: (2022)

Is hyperexcitability really guilty in amyotrophic lateral sclerosis?
por: Leroy, Felix, et al.
Publicado: (2015)

Utility of Transcranial Magnetic Simulation in Studying Upper Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis
por: Geevasinga, Nimeshan, et al.
Publicado: (2021)

Dissociation of Structural and Functional Integrities of the Motor System in Amyotrophic Lateral Sclerosis and Behavioral-Variant Frontotemporal Dementia
por: Bae, Jong Seok, et al.
Publicado: (2016)

Transcranial magnetic stimulation and amyotrophic lateral sclerosis: pathophysiological insights
por: Vucic, Steve, et al.
Publicado: (2013)

Study protocol of RESCUE-ALS: A Phase 2, randomised, double-blind, placebo-controlled study in early symptomatic amyotrophic lateral sclerosis patients to assess bioenergetic catalysis with CNM-Au8 as a mechanism to slow disease progression
por: Vucic, Steve, et al.
Publicado: (2021)

Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms
por: Xie, Manling, et al.
Publicado: (2023)

Corticomotoneuronal function and hyperexcitability in acquired neuromyotonia
por: Vucic, Steve, et al.
Publicado: (2010)

Cortical inexcitability defines an adverse clinical profile in amyotrophic lateral sclerosis
por: Dharmadasa, T., et al.
Publicado: (2020)

Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis
por: Leroy, Félix, et al.
Publicado: (2014)

Efficacy and safety of CNM-Au8 in amyotrophic lateral sclerosis (RESCUE-ALS study): a phase 2, randomised, double-blind, placebo-controlled trial and open label extension
por: Vucic, Steve, et al.
Publicado: (2023)

Motor cortical excitability predicts cognitive phenotypes in amyotrophic lateral sclerosis
por: Agarwal, Smriti, et al.
Publicado: (2021)

Improving clinical trial outcomes in amyotrophic lateral sclerosis
por: Kiernan, Matthew C., et al.
Publicado: (2020)

Sensory Gating during Voluntary Finger Movement in Amyotrophic Lateral Sclerosis with Sensory Cortex Hyperexcitability
por: Shimizu, Toshio, et al.
Publicado: (2023)

Motor cortical function and the precision grip
por: Geevasinga, Nimeshan, et al.
Publicado: (2014)

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis
por: Buskila, Yossi, et al.
Publicado: (2019)

Characterization of Fasciculation Potentials (FPs) in Amyotrophic Lateral Sclerosis (ALS) and Peripheral Nerve Hyperexcitability Syndromes (PNH)
por: Wang, Hua, et al.
Publicado: (2021)

Flecainide in Amyotrophic Lateral Sclerosis as a Neuroprotective Strategy (FANS): A Randomized Placebo-Controlled Trial
por: Park, Susanna B., et al.
Publicado: (2015)

Human cerebral evolution and the clinical syndrome of amyotrophic lateral sclerosis
por: Henderson, Robert D, et al.
Publicado: (2019)

What are the roles of carers in decision-making for amyotrophic lateral sclerosis multidisciplinary care?
por: Hogden, Anne, et al.
Publicado: (2013)

Identification and outcomes of clinical phenotypes in amyotrophic lateral sclerosis/motor neuron disease: Australian National Motor Neuron Disease observational cohort
por: Talman, Paul, et al.
Publicado: (2016)

The Wobbler Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Displays Hippocampal Hyperexcitability, and Reduced Number of Interneurons, but No Presynaptic Vesicle Release Impairments
por: Thielsen, Karina D., et al.
Publicado: (2013)

Cerebellar Integrity in the Amyotrophic Lateral Sclerosis - Frontotemporal Dementia Continuum
por: Tan, Rachel H., et al.
Publicado: (2014)

Phase 2 randomized placebo controlled double blind study to assess the efficacy and safety of tecfidera in patients with amyotrophic lateral sclerosis (TEALS Study): Study protocol clinical trial (SPIRIT Compliant)
por: Vucic, Steve, et al.
Publicado: (2020)

Multiple pathways of lipid dysregulation in amyotrophic lateral sclerosis
por: Phan, Katherine, et al.
Publicado: (2022)

New onset headache caused by histiocytic sarcoma of the spinal cord and leptomeninges: a case report
por: Silsby, Matthew, et al.
Publicado: (2021)

Clinical and research applications of neuromuscular ultrasound in amyotrophic lateral sclerosis
por: Barnes, Stephanie L, et al.
Publicado: (2019)

The Upper Motor Neuron—Improved Knowledge from ALS and Related Clinical Disorders
por: Menon, Parvathi, et al.
Publicado: (2021)

Amyotrophic lateral sclerosis
por: Wijesekera, Lokesh C, et al.
Publicado: (2009)

Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis
por: Katzeff, Jared S., et al.
Publicado: (2022)

Utility of threshold tracking transcranial magnetic stimulation in ALS
por: Vucic, Steve, et al.
Publicado: (2018)

Correction: The Wobbler Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Displays Hippocampal Hyperexcitability, and Reduced Number of Interneurons, but No Presynaptic Vesicle Release Impairments
Publicado: (2015)

Engaging in patient decision-making in multidisciplinary care for amyotrophic lateral sclerosis: the views of health professionals
por: Hogden, Anne, et al.
Publicado: (2012)

Frontostriatal grey matter atrophy in amyotrophic lateral sclerosis A visual rating study
por: Radakovic, Ratko, et al.
Publicado: (2018)

Amyotrophic lateral sclerosis as a synaptopathy
por: Fogarty, Matthew J.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4j9tni1c6f143b0ki14mna54hi