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Parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy
PURPOSE: Parotid gland can be considered as a risk organ in whole brain radiotherapy (WBRT). The purpose of this study is to evaluate the parotid gland sparing effect of computed tomography (CT)-based WBRT compared to 2-dimensional plan with conventional field margin. MATERIALS AND METHODS: From Jan...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society for Radiation Oncology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633226/ https://www.ncbi.nlm.nih.gov/pubmed/23620864 http://dx.doi.org/10.3857/roj.2013.31.1.12 |
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author | Cho, Oyeon Chun, Mison Park, Sung Ho Oh, Young-Taek Kim, Mi-Hwa Park, Hae-Jin Nam, Sang Soo Heo, Jaesung Noh, O Kyu |
author_facet | Cho, Oyeon Chun, Mison Park, Sung Ho Oh, Young-Taek Kim, Mi-Hwa Park, Hae-Jin Nam, Sang Soo Heo, Jaesung Noh, O Kyu |
author_sort | Cho, Oyeon |
collection | PubMed |
description | PURPOSE: Parotid gland can be considered as a risk organ in whole brain radiotherapy (WBRT). The purpose of this study is to evaluate the parotid gland sparing effect of computed tomography (CT)-based WBRT compared to 2-dimensional plan with conventional field margin. MATERIALS AND METHODS: From January 2008 to April 2011, 53 patients underwent WBRT using CT-based simulation. Bilateral two-field arrangement was used and the prescribed dose was 30 Gy in 10 fractions. We compared the parotid dose between 2 radiotherapy plans using different lower field margins: conventional field to the lower level of the atlas (CF) and modified field fitted to the brain tissue (MF). RESULTS: Averages of mean parotid dose of the 2 protocols with CF and MF were 17.4 Gy and 8.7 Gy, respectively (p < 0.001). Mean parotid dose of both glands ≥20 Gy were observed in 15 (28.3%) for CF and in 0 (0.0%) for MF. The whole brain percentage volumes receiving >98% of prescribed dose were 99.7% for CF and 99.5% for MF. CONCLUSION: Compared to WBRT with CF, CT-based lower field margin modification is a simple and effective technique for sparing the parotid gland, while providing similar dose coverage of the whole brain. |
format | Online Article Text |
id | pubmed-3633226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society for Radiation Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-36332262013-04-25 Parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy Cho, Oyeon Chun, Mison Park, Sung Ho Oh, Young-Taek Kim, Mi-Hwa Park, Hae-Jin Nam, Sang Soo Heo, Jaesung Noh, O Kyu Radiat Oncol J Original Article PURPOSE: Parotid gland can be considered as a risk organ in whole brain radiotherapy (WBRT). The purpose of this study is to evaluate the parotid gland sparing effect of computed tomography (CT)-based WBRT compared to 2-dimensional plan with conventional field margin. MATERIALS AND METHODS: From January 2008 to April 2011, 53 patients underwent WBRT using CT-based simulation. Bilateral two-field arrangement was used and the prescribed dose was 30 Gy in 10 fractions. We compared the parotid dose between 2 radiotherapy plans using different lower field margins: conventional field to the lower level of the atlas (CF) and modified field fitted to the brain tissue (MF). RESULTS: Averages of mean parotid dose of the 2 protocols with CF and MF were 17.4 Gy and 8.7 Gy, respectively (p < 0.001). Mean parotid dose of both glands ≥20 Gy were observed in 15 (28.3%) for CF and in 0 (0.0%) for MF. The whole brain percentage volumes receiving >98% of prescribed dose were 99.7% for CF and 99.5% for MF. CONCLUSION: Compared to WBRT with CF, CT-based lower field margin modification is a simple and effective technique for sparing the parotid gland, while providing similar dose coverage of the whole brain. The Korean Society for Radiation Oncology 2013-03 2013-03-31 /pmc/articles/PMC3633226/ /pubmed/23620864 http://dx.doi.org/10.3857/roj.2013.31.1.12 Text en Copyright © 2013. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cho, Oyeon Chun, Mison Park, Sung Ho Oh, Young-Taek Kim, Mi-Hwa Park, Hae-Jin Nam, Sang Soo Heo, Jaesung Noh, O Kyu Parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy |
title | Parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy |
title_full | Parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy |
title_fullStr | Parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy |
title_full_unstemmed | Parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy |
title_short | Parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy |
title_sort | parotid gland sparing effect by computed tomography-based modified lower field margin in whole brain radiotherapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633226/ https://www.ncbi.nlm.nih.gov/pubmed/23620864 http://dx.doi.org/10.3857/roj.2013.31.1.12 |
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