Pharmacophore and 3D-QSAR Characterization of 6-Arylquinazolin-4-amines as Cdc2-like Kinase 4 (Clk4) and Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A (Dyrk1A) Inhibitors

[Image: see text] Cdc2-like kinase 4 (Clk4) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) are protein kinases that are promising targets for treatment of diseases caused by abnormal gene splicing. 6-Arylquinazolin-4-amines have been recently identified as potent Clk4 and...

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Detalles Bibliográficos
Autores principales: Pan, Yongmei, Wang, Yanli, Bryant, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633254/
https://www.ncbi.nlm.nih.gov/pubmed/23496085
http://dx.doi.org/10.1021/ci300625c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633254/
https://www.ncbi.nlm.nih.gov/pubmed/23496085
http://dx.doi.org/10.1021/ci300625c

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