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Conservative management of Beta-thalassemia major cases in the sub-division level hospital of rural West Bengal, India
BACKGROUND: The ideal management of thalassemia involves a multidisciplinary therapeutic team approach and should be preferably done at a comprehensive thalassemia care center with all sorts of specialists and the backup of a well-equipped blood bank. However, in developing country like ours, these...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633258/ https://www.ncbi.nlm.nih.gov/pubmed/23633844 http://dx.doi.org/10.4103/0976-9668.107269 |
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author | Bandyopadhyay, Ujjwal Kundu, Dipankar Sinha, Arijit Banerjee, Kallol Bandyopadhyay, Ranjana Mandal, Tridibeshwar Ray, Debes |
author_facet | Bandyopadhyay, Ujjwal Kundu, Dipankar Sinha, Arijit Banerjee, Kallol Bandyopadhyay, Ranjana Mandal, Tridibeshwar Ray, Debes |
author_sort | Bandyopadhyay, Ujjwal |
collection | PubMed |
description | BACKGROUND: The ideal management of thalassemia involves a multidisciplinary therapeutic team approach and should be preferably done at a comprehensive thalassemia care center with all sorts of specialists and the backup of a well-equipped blood bank. However, in developing country like ours, these facilities are not available in rural set up. So, a situation where conservative therapy with regular blood transfusion is the only choice left to innumerable thalassemic children. OBJECTIVE: To evaluate the existing conservative management protocol of Beta-thalassemia major patients in the setup of a subdivision level Government Hospital of rural West Bengal, India. MATERIALS AND METHODS: The study was performed between December 2009 and December 2011. Beta-thalassemia major patients, registered in blood bank for moderate transfusion regimen, were taken in study. All the patients were screened for Transfusion Transmittable Infections at the time of registration and thereafter periodically every six months. Iron chelation therapy was given simultaneously with transfusion at a dose of 20 to 40 mg/kg/day for six days. The patients were advised to follow up with chelation therapy at home by daily infusion with a goal of maintaining serum ferritin level below 1000 ng/ml. Over this long period of study, the patients were periodically evaluated for complications. RESULTS: The average blood requirement (ml/kg/year) in 1-5 years, 6-10 years, and 11-15 years were 110, 150, and 180, respectively. Incidence of Hepatitis C Virus infection in 1-5 years and 6-10 years were 1.75% and 2.08%, respectively. It is well seen that serum ferritin level increase with ascending age as does the blood consumption. CONCLUSION: Conservative management may be the best alternative and at times the only hope for patients in developing country like ours. However, in order to decrease the disease load, steps need to be taken to introduce preventive measures. |
format | Online Article Text |
id | pubmed-3633258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36332582013-04-30 Conservative management of Beta-thalassemia major cases in the sub-division level hospital of rural West Bengal, India Bandyopadhyay, Ujjwal Kundu, Dipankar Sinha, Arijit Banerjee, Kallol Bandyopadhyay, Ranjana Mandal, Tridibeshwar Ray, Debes J Nat Sci Biol Med Original Article BACKGROUND: The ideal management of thalassemia involves a multidisciplinary therapeutic team approach and should be preferably done at a comprehensive thalassemia care center with all sorts of specialists and the backup of a well-equipped blood bank. However, in developing country like ours, these facilities are not available in rural set up. So, a situation where conservative therapy with regular blood transfusion is the only choice left to innumerable thalassemic children. OBJECTIVE: To evaluate the existing conservative management protocol of Beta-thalassemia major patients in the setup of a subdivision level Government Hospital of rural West Bengal, India. MATERIALS AND METHODS: The study was performed between December 2009 and December 2011. Beta-thalassemia major patients, registered in blood bank for moderate transfusion regimen, were taken in study. All the patients were screened for Transfusion Transmittable Infections at the time of registration and thereafter periodically every six months. Iron chelation therapy was given simultaneously with transfusion at a dose of 20 to 40 mg/kg/day for six days. The patients were advised to follow up with chelation therapy at home by daily infusion with a goal of maintaining serum ferritin level below 1000 ng/ml. Over this long period of study, the patients were periodically evaluated for complications. RESULTS: The average blood requirement (ml/kg/year) in 1-5 years, 6-10 years, and 11-15 years were 110, 150, and 180, respectively. Incidence of Hepatitis C Virus infection in 1-5 years and 6-10 years were 1.75% and 2.08%, respectively. It is well seen that serum ferritin level increase with ascending age as does the blood consumption. CONCLUSION: Conservative management may be the best alternative and at times the only hope for patients in developing country like ours. However, in order to decrease the disease load, steps need to be taken to introduce preventive measures. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3633258/ /pubmed/23633844 http://dx.doi.org/10.4103/0976-9668.107269 Text en Copyright: © Journal of Natural Science, Biology and Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bandyopadhyay, Ujjwal Kundu, Dipankar Sinha, Arijit Banerjee, Kallol Bandyopadhyay, Ranjana Mandal, Tridibeshwar Ray, Debes Conservative management of Beta-thalassemia major cases in the sub-division level hospital of rural West Bengal, India |
title | Conservative management of Beta-thalassemia major cases in the sub-division level hospital of rural West Bengal, India |
title_full | Conservative management of Beta-thalassemia major cases in the sub-division level hospital of rural West Bengal, India |
title_fullStr | Conservative management of Beta-thalassemia major cases in the sub-division level hospital of rural West Bengal, India |
title_full_unstemmed | Conservative management of Beta-thalassemia major cases in the sub-division level hospital of rural West Bengal, India |
title_short | Conservative management of Beta-thalassemia major cases in the sub-division level hospital of rural West Bengal, India |
title_sort | conservative management of beta-thalassemia major cases in the sub-division level hospital of rural west bengal, india |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633258/ https://www.ncbi.nlm.nih.gov/pubmed/23633844 http://dx.doi.org/10.4103/0976-9668.107269 |
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