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Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort
Autism is a complex neuropsychiatric syndrome with a largely unknown etiology. Inflammation during pregnancy may represent a common pathway by which infections and other insults increase risk for the disorder. Hence, we investigated the association between early gestational C-reactive protein (CRP),...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633612/ https://www.ncbi.nlm.nih.gov/pubmed/23337946 http://dx.doi.org/10.1038/mp.2012.197 |
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author | Brown, Alan S. Sourander, Andre Hinkka-Yli-Salomäki, Susanna McKeague, Ian W. Sundvall, Jouko Surcel, Helja-Marja |
author_facet | Brown, Alan S. Sourander, Andre Hinkka-Yli-Salomäki, Susanna McKeague, Ian W. Sundvall, Jouko Surcel, Helja-Marja |
author_sort | Brown, Alan S. |
collection | PubMed |
description | Autism is a complex neuropsychiatric syndrome with a largely unknown etiology. Inflammation during pregnancy may represent a common pathway by which infections and other insults increase risk for the disorder. Hence, we investigated the association between early gestational C-reactive protein (CRP), an established inflammatory biomarker, prospectively assayed in maternal sera, and childhood autism in a large national birth cohort with an extensive serum biobank. Other strengths of the cohort included nearly complete ascertainment of pregnancies in Finland (N=1.2 million) over the study period and national psychiatric registries consisting of virtually all treated autism cases in the population. Increasing maternal CRP levels, classified as a continuous variable, were significantly associated with autism in offspring. For maternal CRP levels in the highest quintile, compared to the lowest quintile, there was a significant, 43% elevated risk. This finding suggests that maternal inflammation may play a significant role in autism, with possible implications for identifying preventive strategies and pathogenic mechanisms in autism and other neurodevelopmental disorders. |
format | Online Article Text |
id | pubmed-3633612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-36336122014-08-01 Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort Brown, Alan S. Sourander, Andre Hinkka-Yli-Salomäki, Susanna McKeague, Ian W. Sundvall, Jouko Surcel, Helja-Marja Mol Psychiatry Article Autism is a complex neuropsychiatric syndrome with a largely unknown etiology. Inflammation during pregnancy may represent a common pathway by which infections and other insults increase risk for the disorder. Hence, we investigated the association between early gestational C-reactive protein (CRP), an established inflammatory biomarker, prospectively assayed in maternal sera, and childhood autism in a large national birth cohort with an extensive serum biobank. Other strengths of the cohort included nearly complete ascertainment of pregnancies in Finland (N=1.2 million) over the study period and national psychiatric registries consisting of virtually all treated autism cases in the population. Increasing maternal CRP levels, classified as a continuous variable, were significantly associated with autism in offspring. For maternal CRP levels in the highest quintile, compared to the lowest quintile, there was a significant, 43% elevated risk. This finding suggests that maternal inflammation may play a significant role in autism, with possible implications for identifying preventive strategies and pathogenic mechanisms in autism and other neurodevelopmental disorders. 2013-01-22 2014-02 /pmc/articles/PMC3633612/ /pubmed/23337946 http://dx.doi.org/10.1038/mp.2012.197 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Brown, Alan S. Sourander, Andre Hinkka-Yli-Salomäki, Susanna McKeague, Ian W. Sundvall, Jouko Surcel, Helja-Marja Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort |
title | Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort |
title_full | Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort |
title_fullStr | Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort |
title_full_unstemmed | Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort |
title_short | Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort |
title_sort | elevated maternal c-reactive protein and autism in a national birth cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633612/ https://www.ncbi.nlm.nih.gov/pubmed/23337946 http://dx.doi.org/10.1038/mp.2012.197 |
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