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Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort

Autism is a complex neuropsychiatric syndrome with a largely unknown etiology. Inflammation during pregnancy may represent a common pathway by which infections and other insults increase risk for the disorder. Hence, we investigated the association between early gestational C-reactive protein (CRP),...

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Autores principales: Brown, Alan S., Sourander, Andre, Hinkka-Yli-Salomäki, Susanna, McKeague, Ian W., Sundvall, Jouko, Surcel, Helja-Marja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633612/
https://www.ncbi.nlm.nih.gov/pubmed/23337946
http://dx.doi.org/10.1038/mp.2012.197
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author Brown, Alan S.
Sourander, Andre
Hinkka-Yli-Salomäki, Susanna
McKeague, Ian W.
Sundvall, Jouko
Surcel, Helja-Marja
author_facet Brown, Alan S.
Sourander, Andre
Hinkka-Yli-Salomäki, Susanna
McKeague, Ian W.
Sundvall, Jouko
Surcel, Helja-Marja
author_sort Brown, Alan S.
collection PubMed
description Autism is a complex neuropsychiatric syndrome with a largely unknown etiology. Inflammation during pregnancy may represent a common pathway by which infections and other insults increase risk for the disorder. Hence, we investigated the association between early gestational C-reactive protein (CRP), an established inflammatory biomarker, prospectively assayed in maternal sera, and childhood autism in a large national birth cohort with an extensive serum biobank. Other strengths of the cohort included nearly complete ascertainment of pregnancies in Finland (N=1.2 million) over the study period and national psychiatric registries consisting of virtually all treated autism cases in the population. Increasing maternal CRP levels, classified as a continuous variable, were significantly associated with autism in offspring. For maternal CRP levels in the highest quintile, compared to the lowest quintile, there was a significant, 43% elevated risk. This finding suggests that maternal inflammation may play a significant role in autism, with possible implications for identifying preventive strategies and pathogenic mechanisms in autism and other neurodevelopmental disorders.
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spelling pubmed-36336122014-08-01 Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort Brown, Alan S. Sourander, Andre Hinkka-Yli-Salomäki, Susanna McKeague, Ian W. Sundvall, Jouko Surcel, Helja-Marja Mol Psychiatry Article Autism is a complex neuropsychiatric syndrome with a largely unknown etiology. Inflammation during pregnancy may represent a common pathway by which infections and other insults increase risk for the disorder. Hence, we investigated the association between early gestational C-reactive protein (CRP), an established inflammatory biomarker, prospectively assayed in maternal sera, and childhood autism in a large national birth cohort with an extensive serum biobank. Other strengths of the cohort included nearly complete ascertainment of pregnancies in Finland (N=1.2 million) over the study period and national psychiatric registries consisting of virtually all treated autism cases in the population. Increasing maternal CRP levels, classified as a continuous variable, were significantly associated with autism in offspring. For maternal CRP levels in the highest quintile, compared to the lowest quintile, there was a significant, 43% elevated risk. This finding suggests that maternal inflammation may play a significant role in autism, with possible implications for identifying preventive strategies and pathogenic mechanisms in autism and other neurodevelopmental disorders. 2013-01-22 2014-02 /pmc/articles/PMC3633612/ /pubmed/23337946 http://dx.doi.org/10.1038/mp.2012.197 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Brown, Alan S.
Sourander, Andre
Hinkka-Yli-Salomäki, Susanna
McKeague, Ian W.
Sundvall, Jouko
Surcel, Helja-Marja
Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort
title Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort
title_full Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort
title_fullStr Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort
title_full_unstemmed Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort
title_short Elevated Maternal C-Reactive Protein and Autism in a National Birth Cohort
title_sort elevated maternal c-reactive protein and autism in a national birth cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633612/
https://www.ncbi.nlm.nih.gov/pubmed/23337946
http://dx.doi.org/10.1038/mp.2012.197
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