High Concentrations of L-Ascorbic Acid Specifically Inhibit the Growth of Human Leukemic Cells via Downregulation of HIF-1α Transcription

We examined the antileukemic effects of high concentrations of L-ascorbic acid (high AA) on human leukemic cells. In vitro, high AA markedly induced apoptosis in various leukemic cell lines by generating hydrogen peroxide (H(2)O(2)) but not in normal hematopoietic stem/progenitor cells. High AA sign...

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Detalles Bibliográficos
Autores principales: Kawada, Hiroshi, Kaneko, Mitsuyo, Sawanobori, Masakazu, Uno, Tomoko, Matsuzawa, Hideyuki, Nakamura, Yoshihiko, Matsushita, Hiromichi, Ando, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633866/
https://www.ncbi.nlm.nih.gov/pubmed/23626851
http://dx.doi.org/10.1371/journal.pone.0062717

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