Severe Liver Cirrhosis Markedly Reduces AhR-Mediated Induction of Cytochrome P450 in Rats by Decreasing the Transcription of Target Genes

Although the induction of cytochrome P450 (CYP) has long been investigated in patients with cirrhosis, the question whether liver dysfunction impairs the response to CYP inducers still remains unresolved. Moreover, the mechanism underlying the possible effect of cirrhosis on induction has not been i...

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Detalles Bibliográficos
Autores principales: Floreani, Maura, De Martin, Sara, Gabbia, Daniela, Barbierato, Massimo, Nassi, Alberto, Mescoli, Claudia, Orlando, Rocco, Bova, Sergio, Angeli, Paolo, Gola, Elisabetta, Sticca, Antonietta, Palatini, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633963/
https://www.ncbi.nlm.nih.gov/pubmed/23626760
http://dx.doi.org/10.1371/journal.pone.0061983

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