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Comparison of Prognostic Genomic Predictors in Colorectal Cancer
BACKGROUND: Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared five prognostic genom...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634034/ https://www.ncbi.nlm.nih.gov/pubmed/23626670 http://dx.doi.org/10.1371/journal.pone.0060778 |
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author | Park, Yun-Yong Lee, Sung Sook Lim, Jae Yun Kim, Sang Cheol Kim, Sang Bae Sohn, Bo Hwa Chu, In-Sun Oh, Sang Cheul Park, Eun Sung Jeong, Woojin Kim, Sung Soo Kopetz, Scott Lee, Ju-Seog |
author_facet | Park, Yun-Yong Lee, Sung Sook Lim, Jae Yun Kim, Sang Cheol Kim, Sang Bae Sohn, Bo Hwa Chu, In-Sun Oh, Sang Cheul Park, Eun Sung Jeong, Woojin Kim, Sung Soo Kopetz, Scott Lee, Ju-Seog |
author_sort | Park, Yun-Yong |
collection | PubMed |
description | BACKGROUND: Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared five prognostic genomic predictors, the V7RHS, the ColoGuideEx, the Meta163, the OncoDX, and the MDA114, in terms of predicting disease-free survival in two independent cohorts of patients with colorectal cancer. STUDY DESIGN: Using original classification algorithms, we tested the predictions of five genomic predictors for disease-free survival in two cohorts of patients with colorectal cancer (n = 229 and n = 168) and evaluated concordance of predictors in predicting outcomes for individual patients. RESULTS: We found that only two predictors, OncoDX and MDA114, demonstrated robust performance in identifying patients with poor prognosis in 2 independent cohorts. These two predictors also had modest but significant concordance of predicted outcome (r>0.3, P<0.001 in both cohorts). CONCLUSIONS: Further validation of developed genomic predictors is necessary. Despite the limited number of genes shared by OncoDX and MDA114, individual-patient outcomes predicted by these two predictors were significantly concordant. |
format | Online Article Text |
id | pubmed-3634034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36340342013-04-26 Comparison of Prognostic Genomic Predictors in Colorectal Cancer Park, Yun-Yong Lee, Sung Sook Lim, Jae Yun Kim, Sang Cheol Kim, Sang Bae Sohn, Bo Hwa Chu, In-Sun Oh, Sang Cheul Park, Eun Sung Jeong, Woojin Kim, Sung Soo Kopetz, Scott Lee, Ju-Seog PLoS One Research Article BACKGROUND: Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared five prognostic genomic predictors, the V7RHS, the ColoGuideEx, the Meta163, the OncoDX, and the MDA114, in terms of predicting disease-free survival in two independent cohorts of patients with colorectal cancer. STUDY DESIGN: Using original classification algorithms, we tested the predictions of five genomic predictors for disease-free survival in two cohorts of patients with colorectal cancer (n = 229 and n = 168) and evaluated concordance of predictors in predicting outcomes for individual patients. RESULTS: We found that only two predictors, OncoDX and MDA114, demonstrated robust performance in identifying patients with poor prognosis in 2 independent cohorts. These two predictors also had modest but significant concordance of predicted outcome (r>0.3, P<0.001 in both cohorts). CONCLUSIONS: Further validation of developed genomic predictors is necessary. Despite the limited number of genes shared by OncoDX and MDA114, individual-patient outcomes predicted by these two predictors were significantly concordant. Public Library of Science 2013-04-23 /pmc/articles/PMC3634034/ /pubmed/23626670 http://dx.doi.org/10.1371/journal.pone.0060778 Text en © 2013 Park et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Park, Yun-Yong Lee, Sung Sook Lim, Jae Yun Kim, Sang Cheol Kim, Sang Bae Sohn, Bo Hwa Chu, In-Sun Oh, Sang Cheul Park, Eun Sung Jeong, Woojin Kim, Sung Soo Kopetz, Scott Lee, Ju-Seog Comparison of Prognostic Genomic Predictors in Colorectal Cancer |
title | Comparison of Prognostic Genomic Predictors in Colorectal Cancer |
title_full | Comparison of Prognostic Genomic Predictors in Colorectal Cancer |
title_fullStr | Comparison of Prognostic Genomic Predictors in Colorectal Cancer |
title_full_unstemmed | Comparison of Prognostic Genomic Predictors in Colorectal Cancer |
title_short | Comparison of Prognostic Genomic Predictors in Colorectal Cancer |
title_sort | comparison of prognostic genomic predictors in colorectal cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634034/ https://www.ncbi.nlm.nih.gov/pubmed/23626670 http://dx.doi.org/10.1371/journal.pone.0060778 |
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