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ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

Accumulation of peptide-linked DNA breaks contributes to neurodegeration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1) and human hereditary ataxia. TDP1 primarily operates at single-strand breaks (SSBs) created by oxidative stress or by collision of transcription m...

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Detalles Bibliográficos
Autores principales:	Alagoz, Meryem, Chiang, Shih-Chieh, Sharma, Abhishek, El-Khamisy, Sherif F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634035/ https://www.ncbi.nlm.nih.gov/pubmed/23626666 http://dx.doi.org/10.1371/journal.pone.0058239

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