Reconstitution of the Anti-Apoptotic Bcl-2 Protein into Lipid Membranes and Biophysical Evidence for Its Detergent-Driven Association with the Pro-Apoptotic Bax Protein

The anti-apoptotic B-cell CLL/lymphoma-2 (Bcl-2) protein and its counterpart, the pro-apoptotic Bcl-2-associated X protein (Bax), are key players in the regulation of the mitochondrial pathway of apoptosis. However, how they interact at the mitochondrial outer membrane (MOM) and there determine whet...

Descripción completa

Detalles Bibliográficos
Autores principales: Wallgren, Marcus, Lidman, Martin, Pedersen, Anders, Brännström, Kristoffer, Karlsson, B. Göran, Gröbner, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634071/
https://www.ncbi.nlm.nih.gov/pubmed/23626686
http://dx.doi.org/10.1371/journal.pone.0061452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634071/
https://www.ncbi.nlm.nih.gov/pubmed/23626686
http://dx.doi.org/10.1371/journal.pone.0061452

Ejemplares similares