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Studying Gene Expression System Regulation at the Program Level
Understanding how gene expression systems influence biological outcomes is an important goal for diverse areas of research. Gene expression profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to use this information to increase biological...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634080/ https://www.ncbi.nlm.nih.gov/pubmed/23626674 http://dx.doi.org/10.1371/journal.pone.0061324 |
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author | Alter, Mark D. |
author_facet | Alter, Mark D. |
author_sort | Alter, Mark D. |
collection | PubMed |
description | Understanding how gene expression systems influence biological outcomes is an important goal for diverse areas of research. Gene expression profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to use this information to increase biological understanding. Yet, the best way to relate this immense amount of information to biological outcomes is far from clear. Here, a novel approach to gene expression systems research is presented that focuses on understanding gene expression systems at the level of gene expression program regulation. It is suggested that such an approach has important advantages over current techniques and may provide novel insights into how gene expression systems are regulated to shape biological outcomes such as the development of disease or response to treatment. |
format | Online Article Text |
id | pubmed-3634080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36340802013-04-26 Studying Gene Expression System Regulation at the Program Level Alter, Mark D. PLoS One Research Article Understanding how gene expression systems influence biological outcomes is an important goal for diverse areas of research. Gene expression profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to use this information to increase biological understanding. Yet, the best way to relate this immense amount of information to biological outcomes is far from clear. Here, a novel approach to gene expression systems research is presented that focuses on understanding gene expression systems at the level of gene expression program regulation. It is suggested that such an approach has important advantages over current techniques and may provide novel insights into how gene expression systems are regulated to shape biological outcomes such as the development of disease or response to treatment. Public Library of Science 2013-04-23 /pmc/articles/PMC3634080/ /pubmed/23626674 http://dx.doi.org/10.1371/journal.pone.0061324 Text en © 2013 Mark D http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Alter, Mark D. Studying Gene Expression System Regulation at the Program Level |
title | Studying Gene Expression System Regulation at the Program Level |
title_full | Studying Gene Expression System Regulation at the Program Level |
title_fullStr | Studying Gene Expression System Regulation at the Program Level |
title_full_unstemmed | Studying Gene Expression System Regulation at the Program Level |
title_short | Studying Gene Expression System Regulation at the Program Level |
title_sort | studying gene expression system regulation at the program level |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634080/ https://www.ncbi.nlm.nih.gov/pubmed/23626674 http://dx.doi.org/10.1371/journal.pone.0061324 |
work_keys_str_mv | AT altermarkd studyinggeneexpressionsystemregulationattheprogramlevel |