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Studying Gene Expression System Regulation at the Program Level

Understanding how gene expression systems influence biological outcomes is an important goal for diverse areas of research. Gene expression profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to use this information to increase biological...

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Detalles Bibliográficos
Autor principal: Alter, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634080/
https://www.ncbi.nlm.nih.gov/pubmed/23626674
http://dx.doi.org/10.1371/journal.pone.0061324
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author Alter, Mark D.
author_facet Alter, Mark D.
author_sort Alter, Mark D.
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description Understanding how gene expression systems influence biological outcomes is an important goal for diverse areas of research. Gene expression profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to use this information to increase biological understanding. Yet, the best way to relate this immense amount of information to biological outcomes is far from clear. Here, a novel approach to gene expression systems research is presented that focuses on understanding gene expression systems at the level of gene expression program regulation. It is suggested that such an approach has important advantages over current techniques and may provide novel insights into how gene expression systems are regulated to shape biological outcomes such as the development of disease or response to treatment.
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spelling pubmed-36340802013-04-26 Studying Gene Expression System Regulation at the Program Level Alter, Mark D. PLoS One Research Article Understanding how gene expression systems influence biological outcomes is an important goal for diverse areas of research. Gene expression profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to use this information to increase biological understanding. Yet, the best way to relate this immense amount of information to biological outcomes is far from clear. Here, a novel approach to gene expression systems research is presented that focuses on understanding gene expression systems at the level of gene expression program regulation. It is suggested that such an approach has important advantages over current techniques and may provide novel insights into how gene expression systems are regulated to shape biological outcomes such as the development of disease or response to treatment. Public Library of Science 2013-04-23 /pmc/articles/PMC3634080/ /pubmed/23626674 http://dx.doi.org/10.1371/journal.pone.0061324 Text en © 2013 Mark D http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Alter, Mark D.
Studying Gene Expression System Regulation at the Program Level
title Studying Gene Expression System Regulation at the Program Level
title_full Studying Gene Expression System Regulation at the Program Level
title_fullStr Studying Gene Expression System Regulation at the Program Level
title_full_unstemmed Studying Gene Expression System Regulation at the Program Level
title_short Studying Gene Expression System Regulation at the Program Level
title_sort studying gene expression system regulation at the program level
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634080/
https://www.ncbi.nlm.nih.gov/pubmed/23626674
http://dx.doi.org/10.1371/journal.pone.0061324
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