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Comparison of Newborn Outcomes in Women with Gestational Diabetes Mellitus Treated with Metformin or Insulin: A Randomised Blinded Trial

BACKGROUND: Few studies have been done on the use of metformin in pregnancy and their results were not similar, therefore this research is performed to compare neonatal outcomes of metformin and insulin in the treatment of gestational diabetes. METHODS: In this prospective randomized trial, 200 preg...

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Autores principales: Mesdaghinia, Elahe, Samimi, Mansoureh, Homaei, Zhila, Saberi, Farzaneh, Moosavi, Seyyed Gholam Abbas, Yaribakht, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634172/
https://www.ncbi.nlm.nih.gov/pubmed/23626890
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author Mesdaghinia, Elahe
Samimi, Mansoureh
Homaei, Zhila
Saberi, Farzaneh
Moosavi, Seyyed Gholam Abbas
Yaribakht, Mohammad
author_facet Mesdaghinia, Elahe
Samimi, Mansoureh
Homaei, Zhila
Saberi, Farzaneh
Moosavi, Seyyed Gholam Abbas
Yaribakht, Mohammad
author_sort Mesdaghinia, Elahe
collection PubMed
description BACKGROUND: Few studies have been done on the use of metformin in pregnancy and their results were not similar, therefore this research is performed to compare neonatal outcomes of metformin and insulin in the treatment of gestational diabetes. METHODS: In this prospective randomized trial, 200 pregnant women within their 24(th) to 34(th) weeks of gestation with gestational diabetes, single fetus pregnancy, and in need of hyperglycemia treatment were entered and grouped as either metformin or insulin. Data related to maternal and neonatal outcomes were recorded and analyzed. RESULTS: Considering data recorded of HbA(1c) at the beginning of pregnancy, pregnancy induced hypertension, preeclampsia, birth weight, dystocia, first and 5(th) min APGAR, neonatal sepsis, rout of delivery, liver function tests of neonate, hypoglycemia, anomaly, and still birth, there were no significant statistical differences between groups. The end pregnancy HbA(1c), maternal weight gain during pregnancy, preterm labor, neonatal jaundice, respiratory distress and hospitalization of infants were higher in insulin group. CONCLUSIONS: Considering data from this study, metformin is efficient to control hyperglycemia in pregnancy. It is suggested performing more studies to evaluate long term side effects of metformin in pregnancy with higher sample size and longer follow-up of newborns.
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spelling pubmed-36341722013-04-26 Comparison of Newborn Outcomes in Women with Gestational Diabetes Mellitus Treated with Metformin or Insulin: A Randomised Blinded Trial Mesdaghinia, Elahe Samimi, Mansoureh Homaei, Zhila Saberi, Farzaneh Moosavi, Seyyed Gholam Abbas Yaribakht, Mohammad Int J Prev Med Original Article BACKGROUND: Few studies have been done on the use of metformin in pregnancy and their results were not similar, therefore this research is performed to compare neonatal outcomes of metformin and insulin in the treatment of gestational diabetes. METHODS: In this prospective randomized trial, 200 pregnant women within their 24(th) to 34(th) weeks of gestation with gestational diabetes, single fetus pregnancy, and in need of hyperglycemia treatment were entered and grouped as either metformin or insulin. Data related to maternal and neonatal outcomes were recorded and analyzed. RESULTS: Considering data recorded of HbA(1c) at the beginning of pregnancy, pregnancy induced hypertension, preeclampsia, birth weight, dystocia, first and 5(th) min APGAR, neonatal sepsis, rout of delivery, liver function tests of neonate, hypoglycemia, anomaly, and still birth, there were no significant statistical differences between groups. The end pregnancy HbA(1c), maternal weight gain during pregnancy, preterm labor, neonatal jaundice, respiratory distress and hospitalization of infants were higher in insulin group. CONCLUSIONS: Considering data from this study, metformin is efficient to control hyperglycemia in pregnancy. It is suggested performing more studies to evaluate long term side effects of metformin in pregnancy with higher sample size and longer follow-up of newborns. Medknow Publications & Media Pvt Ltd 2013-03 /pmc/articles/PMC3634172/ /pubmed/23626890 Text en Copyright: © International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mesdaghinia, Elahe
Samimi, Mansoureh
Homaei, Zhila
Saberi, Farzaneh
Moosavi, Seyyed Gholam Abbas
Yaribakht, Mohammad
Comparison of Newborn Outcomes in Women with Gestational Diabetes Mellitus Treated with Metformin or Insulin: A Randomised Blinded Trial
title Comparison of Newborn Outcomes in Women with Gestational Diabetes Mellitus Treated with Metformin or Insulin: A Randomised Blinded Trial
title_full Comparison of Newborn Outcomes in Women with Gestational Diabetes Mellitus Treated with Metformin or Insulin: A Randomised Blinded Trial
title_fullStr Comparison of Newborn Outcomes in Women with Gestational Diabetes Mellitus Treated with Metformin or Insulin: A Randomised Blinded Trial
title_full_unstemmed Comparison of Newborn Outcomes in Women with Gestational Diabetes Mellitus Treated with Metformin or Insulin: A Randomised Blinded Trial
title_short Comparison of Newborn Outcomes in Women with Gestational Diabetes Mellitus Treated with Metformin or Insulin: A Randomised Blinded Trial
title_sort comparison of newborn outcomes in women with gestational diabetes mellitus treated with metformin or insulin: a randomised blinded trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634172/
https://www.ncbi.nlm.nih.gov/pubmed/23626890
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