Ubiquitinations in the Notch Signaling Pathway

The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules. This inter-cellular contact initiate...

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Detalles Bibliográficos
Autores principales: Moretti, Julien, Brou, Christel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634445/
https://www.ncbi.nlm.nih.gov/pubmed/23519106
http://dx.doi.org/10.3390/ijms14036359
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author Moretti, Julien
Brou, Christel
author_facet Moretti, Julien
Brou, Christel
author_sort Moretti, Julien
collection PubMed
description The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules. This inter-cellular contact initiates a cascade of events eventually transforming the cell surface receptor into a nuclear factor acting on the transcription of specific target genes. This review highlights how the various processes undergone by Notch receptors and ligands that regulate the pathway are linked to ubiquitination events.
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spelling pubmed-36344452013-05-02 Ubiquitinations in the Notch Signaling Pathway Moretti, Julien Brou, Christel Int J Mol Sci Review The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules. This inter-cellular contact initiates a cascade of events eventually transforming the cell surface receptor into a nuclear factor acting on the transcription of specific target genes. This review highlights how the various processes undergone by Notch receptors and ligands that regulate the pathway are linked to ubiquitination events. Molecular Diversity Preservation International (MDPI) 2013-03-19 /pmc/articles/PMC3634445/ /pubmed/23519106 http://dx.doi.org/10.3390/ijms14036359 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Moretti, Julien
Brou, Christel
Ubiquitinations in the Notch Signaling Pathway
title Ubiquitinations in the Notch Signaling Pathway
title_full Ubiquitinations in the Notch Signaling Pathway
title_fullStr Ubiquitinations in the Notch Signaling Pathway
title_full_unstemmed Ubiquitinations in the Notch Signaling Pathway
title_short Ubiquitinations in the Notch Signaling Pathway
title_sort ubiquitinations in the notch signaling pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634445/
https://www.ncbi.nlm.nih.gov/pubmed/23519106
http://dx.doi.org/10.3390/ijms14036359
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