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Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving APP...

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Detalles Bibliográficos
Autores principales:	Grimm, Marcus O. W., Haupenthal, Viola J., Rothhaar, Tatjana L., Zimmer, Valerie C., Grösgen, Sven, Hundsdörfer, Benjamin, Lehmann, Johannes, Grimm, Heike S., Hartmann, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634454/ https://www.ncbi.nlm.nih.gov/pubmed/23485990 http://dx.doi.org/10.3390/ijms14035879

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