Long Non-Coding RNA in Cancer

Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating...

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Detalles Bibliográficos
Autores principales: Hauptman, Nina, Glavač, Damjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634483/
https://www.ncbi.nlm.nih.gov/pubmed/23443164
http://dx.doi.org/10.3390/ijms14034655
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author Hauptman, Nina
Glavač, Damjan
author_facet Hauptman, Nina
Glavač, Damjan
author_sort Hauptman, Nina
collection PubMed
description Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. In this review, we will summarize their emerging role in human cancer and discuss their perspectives in diagnostics as potential biomarkers.
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spelling pubmed-36344832013-05-02 Long Non-Coding RNA in Cancer Hauptman, Nina Glavač, Damjan Int J Mol Sci Review Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. In this review, we will summarize their emerging role in human cancer and discuss their perspectives in diagnostics as potential biomarkers. Molecular Diversity Preservation International (MDPI) 2013-02-26 /pmc/articles/PMC3634483/ /pubmed/23443164 http://dx.doi.org/10.3390/ijms14034655 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Hauptman, Nina
Glavač, Damjan
Long Non-Coding RNA in Cancer
title Long Non-Coding RNA in Cancer
title_full Long Non-Coding RNA in Cancer
title_fullStr Long Non-Coding RNA in Cancer
title_full_unstemmed Long Non-Coding RNA in Cancer
title_short Long Non-Coding RNA in Cancer
title_sort long non-coding rna in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634483/
https://www.ncbi.nlm.nih.gov/pubmed/23443164
http://dx.doi.org/10.3390/ijms14034655
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