MUSTN1 mRNA Abundance and Protein Localization is Greatest in Muscle Tissues of Chinese Meat-Quality Chickens

The Mustang, Musculoskeletal Temporally Activated Novel-1 Gene (MUSTN1) plays an important role in regulating musculoskeletal development in mammals. We evaluated the developmental and tissue-specific regulation of MUSTN1 mRNA and protein abundance in Erlang Mountainous (EM) chickens. Results indica...

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Autores principales: Li, Juan, Chen, Yang, Wang, Ya-Gang, Zhao, Xiao-Ling, Gilbert, Elizabeth Ruth, Liu, Yi-Ping, Wang, Yan, Hu, Yao-Dong, Zhu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634495/
https://www.ncbi.nlm.nih.gov/pubmed/23528857
http://dx.doi.org/10.3390/ijms14035545
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author Li, Juan
Chen, Yang
Wang, Ya-Gang
Zhao, Xiao-Ling
Gilbert, Elizabeth Ruth
Liu, Yi-Ping
Wang, Yan
Hu, Yao-Dong
Zhu, Qing
author_facet Li, Juan
Chen, Yang
Wang, Ya-Gang
Zhao, Xiao-Ling
Gilbert, Elizabeth Ruth
Liu, Yi-Ping
Wang, Yan
Hu, Yao-Dong
Zhu, Qing
author_sort Li, Juan
collection PubMed
description The Mustang, Musculoskeletal Temporally Activated Novel-1 Gene (MUSTN1) plays an important role in regulating musculoskeletal development in mammals. We evaluated the developmental and tissue-specific regulation of MUSTN1 mRNA and protein abundance in Erlang Mountainous (EM) chickens. Results indicated that MUSTN1 mRNA/protein was expressed in most tissues with especially high expression in heart and skeletal muscle. The MUSTN1 protein localized to the nucleus in myocardium and skeletal muscle fibers. There were significant differences in mRNA and protein abundance among tissues, ages and between males and females. In conclusion, MUSTN1 was expressed the greatest in skeletal muscle where it localized to the nucleus. Thus, in chickens MUSTN1 may play a vital role in muscle development.
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spelling pubmed-36344952013-05-02 MUSTN1 mRNA Abundance and Protein Localization is Greatest in Muscle Tissues of Chinese Meat-Quality Chickens Li, Juan Chen, Yang Wang, Ya-Gang Zhao, Xiao-Ling Gilbert, Elizabeth Ruth Liu, Yi-Ping Wang, Yan Hu, Yao-Dong Zhu, Qing Int J Mol Sci Article The Mustang, Musculoskeletal Temporally Activated Novel-1 Gene (MUSTN1) plays an important role in regulating musculoskeletal development in mammals. We evaluated the developmental and tissue-specific regulation of MUSTN1 mRNA and protein abundance in Erlang Mountainous (EM) chickens. Results indicated that MUSTN1 mRNA/protein was expressed in most tissues with especially high expression in heart and skeletal muscle. The MUSTN1 protein localized to the nucleus in myocardium and skeletal muscle fibers. There were significant differences in mRNA and protein abundance among tissues, ages and between males and females. In conclusion, MUSTN1 was expressed the greatest in skeletal muscle where it localized to the nucleus. Thus, in chickens MUSTN1 may play a vital role in muscle development. Molecular Diversity Preservation International (MDPI) 2013-03-08 /pmc/articles/PMC3634495/ /pubmed/23528857 http://dx.doi.org/10.3390/ijms14035545 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Juan
Chen, Yang
Wang, Ya-Gang
Zhao, Xiao-Ling
Gilbert, Elizabeth Ruth
Liu, Yi-Ping
Wang, Yan
Hu, Yao-Dong
Zhu, Qing
MUSTN1 mRNA Abundance and Protein Localization is Greatest in Muscle Tissues of Chinese Meat-Quality Chickens
title MUSTN1 mRNA Abundance and Protein Localization is Greatest in Muscle Tissues of Chinese Meat-Quality Chickens
title_full MUSTN1 mRNA Abundance and Protein Localization is Greatest in Muscle Tissues of Chinese Meat-Quality Chickens
title_fullStr MUSTN1 mRNA Abundance and Protein Localization is Greatest in Muscle Tissues of Chinese Meat-Quality Chickens
title_full_unstemmed MUSTN1 mRNA Abundance and Protein Localization is Greatest in Muscle Tissues of Chinese Meat-Quality Chickens
title_short MUSTN1 mRNA Abundance and Protein Localization is Greatest in Muscle Tissues of Chinese Meat-Quality Chickens
title_sort mustn1 mrna abundance and protein localization is greatest in muscle tissues of chinese meat-quality chickens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634495/
https://www.ncbi.nlm.nih.gov/pubmed/23528857
http://dx.doi.org/10.3390/ijms14035545
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