UPR Signal Activation by Luminal Sensor Domains

The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains...

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Detalles Bibliográficos
Autores principales: Carrara, Marta, Prischi, Filippo, Ali, Maruf M. U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634511/
https://www.ncbi.nlm.nih.gov/pubmed/23519110
http://dx.doi.org/10.3390/ijms14036454
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author Carrara, Marta
Prischi, Filippo
Ali, Maruf M. U.
author_facet Carrara, Marta
Prischi, Filippo
Ali, Maruf M. U.
author_sort Carrara, Marta
collection PubMed
description The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-transducer proteins IRE1, PERK, and ATF6, which then propagate the signal to the cytosol. In this review, we discuss the various mechanisms of action that have been proposed on how the sensor domains detect the presence of unfolded protein to activate downstream UPR signaling.
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spelling pubmed-36345112013-05-02 UPR Signal Activation by Luminal Sensor Domains Carrara, Marta Prischi, Filippo Ali, Maruf M. U. Int J Mol Sci Review The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-transducer proteins IRE1, PERK, and ATF6, which then propagate the signal to the cytosol. In this review, we discuss the various mechanisms of action that have been proposed on how the sensor domains detect the presence of unfolded protein to activate downstream UPR signaling. Molecular Diversity Preservation International (MDPI) 2013-03-21 /pmc/articles/PMC3634511/ /pubmed/23519110 http://dx.doi.org/10.3390/ijms14036454 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Carrara, Marta
Prischi, Filippo
Ali, Maruf M. U.
UPR Signal Activation by Luminal Sensor Domains
title UPR Signal Activation by Luminal Sensor Domains
title_full UPR Signal Activation by Luminal Sensor Domains
title_fullStr UPR Signal Activation by Luminal Sensor Domains
title_full_unstemmed UPR Signal Activation by Luminal Sensor Domains
title_short UPR Signal Activation by Luminal Sensor Domains
title_sort upr signal activation by luminal sensor domains
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634511/
https://www.ncbi.nlm.nih.gov/pubmed/23519110
http://dx.doi.org/10.3390/ijms14036454
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AT prischifilippo uprsignalactivationbyluminalsensordomains
AT alimarufmu uprsignalactivationbyluminalsensordomains

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