Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells

There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent i...

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Detalles Bibliográficos
Autores principales: Kunnimalaiyaan, Muthusamy, Haymart, Megan R., Chen, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634621/
https://www.ncbi.nlm.nih.gov/pubmed/23641144
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author Kunnimalaiyaan, Muthusamy
Haymart, Megan R.
Chen, Herbert
author_facet Kunnimalaiyaan, Muthusamy
Haymart, Megan R.
Chen, Herbert
author_sort Kunnimalaiyaan, Muthusamy
collection PubMed
description There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC.
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spelling pubmed-36346212013-05-02 Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells Kunnimalaiyaan, Muthusamy Haymart, Megan R. Chen, Herbert Transl Oncogenomics Original Research There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC. Libertas Academica 2007-05-03 /pmc/articles/PMC3634621/ /pubmed/23641144 Text en © 2007 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Original Research
Kunnimalaiyaan, Muthusamy
Haymart, Megan R.
Chen, Herbert
Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells
title Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells
title_full Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells
title_fullStr Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells
title_full_unstemmed Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells
title_short Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells
title_sort tumor suppressor role of notch1 and raf-1 signaling in medullary thyroid cancer cells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634621/
https://www.ncbi.nlm.nih.gov/pubmed/23641144
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AT chenherbert tumorsuppressorroleofnotch1andraf1signalinginmedullarythyroidcancercells

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