Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease

Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous condition characterized by peripheral axon degeneration with subsequent motor and sensory deficits. Several CMT gene products function in endosomal sorting and trafficking to the lysosome, suggesting that defects in this...

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Detalles Bibliográficos
Autores principales: Bogdanik, Laurent P., Sleigh, James N., Tian, Cong, Samuels, Mark E., Bedard, Karen, Seburn, Kevin L., Burgess, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634660/
https://www.ncbi.nlm.nih.gov/pubmed/23519028
http://dx.doi.org/10.1242/dmm.010942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634660/
https://www.ncbi.nlm.nih.gov/pubmed/23519028
http://dx.doi.org/10.1242/dmm.010942

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