Glycosylation on Hemagglutinin Affects the Virulence and Pathogenicity of Pandemic H1N1/2009 Influenza A Virus in Mice

The two glycosylation sites (Asn142 and Asn177) were observed in the HA of most human seasonal influenza A/H1N1 viruses, while none in pandemic H1N1/2009 influenza A (pH1N1) viruses. We investigated the effect of the two glycosylation sites on viral virulence and pathogenicity in mice using recombin...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Zhu, Jiping, Li, Yongtao, Bradley, Konrad C., Cao, Jiyue, Chen, Huanchun, Jin, Meilin, Zhou, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634815/
https://www.ncbi.nlm.nih.gov/pubmed/23637827
http://dx.doi.org/10.1371/journal.pone.0061397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634815/
https://www.ncbi.nlm.nih.gov/pubmed/23637827
http://dx.doi.org/10.1371/journal.pone.0061397

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