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Risk of Generalized Vitiligo is Associated with the Common 55R-94A-247H Variant Haplotype of GZMB (Encoding Granzyme B)
Generalized vitiligo (GV) is characterized by autoimmune destruction of melanocytes by skin-homing cytotoxic T-cells (CTLs) that target melanocyte autoantigens. Two recent genomewide association studies (GWAS) of GV in European-derived whites (EUR) have demonstrated genetic association with GZMB, en...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634907/ https://www.ncbi.nlm.nih.gov/pubmed/23321921 http://dx.doi.org/10.1038/jid.2013.5 |