Cargando…
Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation
Malnutrition is a common cause of secondary immune deficiency and has been linked to an increased susceptibility to infection in humans. Malnutrition specifically affects T-cell-mediated immune responses. The aim of this study was to assess in lymphocytes from malnourished children the expression le...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635214/ https://www.ncbi.nlm.nih.gov/pubmed/23429441 http://dx.doi.org/10.3390/nu5020579 |
_version_ | 1782267200366706688 |
---|---|
author | González-Torres, Cristina González-Martínez, Haydeé Miliar, Angel Nájera, Oralia Graniel, Jaime Firo, Verónica Alvarez, Catalina Bonilla, Edmundo Rodríguez, Leonor |
author_facet | González-Torres, Cristina González-Martínez, Haydeé Miliar, Angel Nájera, Oralia Graniel, Jaime Firo, Verónica Alvarez, Catalina Bonilla, Edmundo Rodríguez, Leonor |
author_sort | González-Torres, Cristina |
collection | PubMed |
description | Malnutrition is a common cause of secondary immune deficiency and has been linked to an increased susceptibility to infection in humans. Malnutrition specifically affects T-cell-mediated immune responses. The aim of this study was to assess in lymphocytes from malnourished children the expression levels of IL-12, IL-18 and IL-21, molecules that induce the differentiation of T cells related to the immunological cellular response (Th1 response) and the production of cytokines related to the immunological cellular response (Th1 cytokines). We found that the expression levels of IL-12, IL-18 and IL-21 were significantly diminished in malnourished children compared to well-nourished children and were coincident with lower plasmatic levels of IL-2 and IFN-γ (Th1 cytokines). In this study, we show for the first time that the gene expression and intracellular production of cytokines responsible for Th1 cell differentiation (IL-12, IL-18 and IL-21) are diminished in malnourished children. As expected, this finding was related to lower plasmatic levels of IL-2 and IFN-γ. The decreased expression of Th1 cytokines observed in this study may contribute to the deterioration of the immunological Type 1 (cellular) response. We hypothesize that the decreased production of IL-12, IL-18 and IL-21 in malnourished children contributes to their inability to eradicate infections. |
format | Online Article Text |
id | pubmed-3635214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-36352142013-05-02 Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation González-Torres, Cristina González-Martínez, Haydeé Miliar, Angel Nájera, Oralia Graniel, Jaime Firo, Verónica Alvarez, Catalina Bonilla, Edmundo Rodríguez, Leonor Nutrients Article Malnutrition is a common cause of secondary immune deficiency and has been linked to an increased susceptibility to infection in humans. Malnutrition specifically affects T-cell-mediated immune responses. The aim of this study was to assess in lymphocytes from malnourished children the expression levels of IL-12, IL-18 and IL-21, molecules that induce the differentiation of T cells related to the immunological cellular response (Th1 response) and the production of cytokines related to the immunological cellular response (Th1 cytokines). We found that the expression levels of IL-12, IL-18 and IL-21 were significantly diminished in malnourished children compared to well-nourished children and were coincident with lower plasmatic levels of IL-2 and IFN-γ (Th1 cytokines). In this study, we show for the first time that the gene expression and intracellular production of cytokines responsible for Th1 cell differentiation (IL-12, IL-18 and IL-21) are diminished in malnourished children. As expected, this finding was related to lower plasmatic levels of IL-2 and IFN-γ. The decreased expression of Th1 cytokines observed in this study may contribute to the deterioration of the immunological Type 1 (cellular) response. We hypothesize that the decreased production of IL-12, IL-18 and IL-21 in malnourished children contributes to their inability to eradicate infections. MDPI 2013-02-19 /pmc/articles/PMC3635214/ /pubmed/23429441 http://dx.doi.org/10.3390/nu5020579 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article González-Torres, Cristina González-Martínez, Haydeé Miliar, Angel Nájera, Oralia Graniel, Jaime Firo, Verónica Alvarez, Catalina Bonilla, Edmundo Rodríguez, Leonor Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation |
title | Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation |
title_full | Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation |
title_fullStr | Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation |
title_full_unstemmed | Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation |
title_short | Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation |
title_sort | effect of malnutrition on the expression of cytokines involved in th1 cell differentiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635214/ https://www.ncbi.nlm.nih.gov/pubmed/23429441 http://dx.doi.org/10.3390/nu5020579 |
work_keys_str_mv | AT gonzaleztorrescristina effectofmalnutritionontheexpressionofcytokinesinvolvedinth1celldifferentiation AT gonzalezmartinezhaydee effectofmalnutritionontheexpressionofcytokinesinvolvedinth1celldifferentiation AT miliarangel effectofmalnutritionontheexpressionofcytokinesinvolvedinth1celldifferentiation AT najeraoralia effectofmalnutritionontheexpressionofcytokinesinvolvedinth1celldifferentiation AT granieljaime effectofmalnutritionontheexpressionofcytokinesinvolvedinth1celldifferentiation AT firoveronica effectofmalnutritionontheexpressionofcytokinesinvolvedinth1celldifferentiation AT alvarezcatalina effectofmalnutritionontheexpressionofcytokinesinvolvedinth1celldifferentiation AT bonillaedmundo effectofmalnutritionontheexpressionofcytokinesinvolvedinth1celldifferentiation AT rodriguezleonor effectofmalnutritionontheexpressionofcytokinesinvolvedinth1celldifferentiation |