Cargando…
Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor
We describe the case of a 5-year-old girl whose abdominal pain and distension were caused by Wilms tumor of the kidney. Because of the bilateral nature of her disease, she was spared biopsy or initial nephrectomy as part of her treatment course. Rather, she was treated presumptively for Wilms tumor...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635223/ https://www.ncbi.nlm.nih.gov/pubmed/24964423 http://dx.doi.org/10.1093/jscr/rjt012 |
_version_ | 1782267202185986048 |
---|---|
author | Carmichael, Samuel P. Pulliam, Joseph F. D'Orazio, John A. |
author_facet | Carmichael, Samuel P. Pulliam, Joseph F. D'Orazio, John A. |
author_sort | Carmichael, Samuel P. |
collection | PubMed |
description | We describe the case of a 5-year-old girl whose abdominal pain and distension were caused by Wilms tumor of the kidney. Because of the bilateral nature of her disease, she was spared biopsy or initial nephrectomy as part of her treatment course. Rather, she was treated presumptively for Wilms tumor based primarily on radiologic findings. Neoadjuvant chemotherapy consisting of vincristine, dactinomycin and doxorubicin was given to facilitate nephron-sparing surgery for tumor resection. Her initial chemotherapeutic course was complicated by tumor lysis syndrome manifested by elevated serum uric acid and was treated effectively with hyperhydration and alkalization of intravenous fluids. The patient's disease responded well to chemotherapy, and she underwent successful tumor excision after 12 weeks of chemotherapy. The resected tumor was identified as anaplastic Wilms tumor, illustrating that pathologic identification of Wilms tumor is possible even after multiple cycles of neoadjuvant chemotherapy and marked tumor shrinkage. |
format | Online Article Text |
id | pubmed-3635223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36352232013-04-25 Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor Carmichael, Samuel P. Pulliam, Joseph F. D'Orazio, John A. J Surg Case Rep Case Reports We describe the case of a 5-year-old girl whose abdominal pain and distension were caused by Wilms tumor of the kidney. Because of the bilateral nature of her disease, she was spared biopsy or initial nephrectomy as part of her treatment course. Rather, she was treated presumptively for Wilms tumor based primarily on radiologic findings. Neoadjuvant chemotherapy consisting of vincristine, dactinomycin and doxorubicin was given to facilitate nephron-sparing surgery for tumor resection. Her initial chemotherapeutic course was complicated by tumor lysis syndrome manifested by elevated serum uric acid and was treated effectively with hyperhydration and alkalization of intravenous fluids. The patient's disease responded well to chemotherapy, and she underwent successful tumor excision after 12 weeks of chemotherapy. The resected tumor was identified as anaplastic Wilms tumor, illustrating that pathologic identification of Wilms tumor is possible even after multiple cycles of neoadjuvant chemotherapy and marked tumor shrinkage. Oxford University Press 2013-03 2012-03-12 /pmc/articles/PMC3635223/ /pubmed/24964423 http://dx.doi.org/10.1093/jscr/rjt012 Text en Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author 2013. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com. |
spellingShingle | Case Reports Carmichael, Samuel P. Pulliam, Joseph F. D'Orazio, John A. Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor |
title | Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor |
title_full | Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor |
title_fullStr | Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor |
title_full_unstemmed | Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor |
title_short | Delayed tumor resection in a 5-year-old child with bilateral Wilms tumor |
title_sort | delayed tumor resection in a 5-year-old child with bilateral wilms tumor |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635223/ https://www.ncbi.nlm.nih.gov/pubmed/24964423 http://dx.doi.org/10.1093/jscr/rjt012 |
work_keys_str_mv | AT carmichaelsamuelp delayedtumorresectionina5yearoldchildwithbilateralwilmstumor AT pulliamjosephf delayedtumorresectionina5yearoldchildwithbilateralwilmstumor AT doraziojohna delayedtumorresectionina5yearoldchildwithbilateralwilmstumor |